Baylor College of Medicine, Houston, Texas.
Texas Children's Hospital, Houston, Texas.
J Clin Sleep Med. 2021 Jun 1;17(6):1193-1200. doi: 10.5664/jcsm.9166.
Research indicates a deleterious effect of sleep disturbances on pain and illness-related functioning across pediatric populations. Sleep problems in youth with functional gastrointestinal disorders (FGIDs) are understudied, despite studies in adult FGIDs indicating sleep disruptions increase pain and symptom severity. This study sought to better characterize sleep problems in school-age children with FGIDs and to assess relationships with demographic characteristics and gastrointestinal symptoms.
Sixty-seven children with FGIDs (pediatric Rome IV criteria) and 59 parents completed questionnaires assessing sleep problems, and children completed a 2-week pain/stooling diary. Sleep problems in this sample were compared with published normative samples, and children above and below the clinical cutoff were compared on demographics and FGID symptoms.
Of the sample, 61% were above the clinical cutoff for sleep disturbances, with significantly greater bedtime resistance, sleep onset delay, sleep duration, and daytime sleepiness than the comparison group. Children above the clinical cutoff reported greater mean abdominal pain severity and pain interference. Relative to White participants, Black/African-American participants were more likely to be above the clinical cutoff and indicated more frequent night wakening and symptoms of sleep-disordered breathing, but lower maximum and overall mean abdominal pain severity.
Sleep problems in children with FGIDs are common and related to greater day-to-day abdominal pain severity and pain interference. Results suggest sleep-pain relationships may differ across racial/ethnic groups. Assessing sleep in children with FGIDs is important, and further research is needed to assess underlying mechanisms and evaluate sleep as a potential treatment target in this population.
研究表明，睡眠障碍对儿科人群的疼痛和与疾病相关的功能有不良影响。尽管成人功能性胃肠道疾病（FGIDs）的研究表明睡眠中断会增加疼痛和症状严重程度，但青少年 FGIDs 中的睡眠问题研究较少。本研究旨在更好地描述 FGIDs 学龄儿童的睡眠问题，并评估其与人口统计学特征和胃肠道症状的关系。
67 名 FGIDs 儿童（儿科 Rome IV 标准）和 59 名父母完成了评估睡眠问题的问卷，儿童完成了为期 2 周的疼痛/排便日记。该样本中的睡眠问题与已发表的正常样本进行了比较，并且在人口统计学特征和 FGID 症状方面，高于和低于临床截止值的儿童进行了比较。
在该样本中，61%的儿童存在睡眠障碍的临床截止值以上，与对照组相比，入睡抵抗、入睡潜伏期、睡眠时间和白天嗜睡明显增加。高于临床截止值的儿童报告了更严重的平均腹痛严重程度和疼痛干扰。与白人参与者相比，黑人和非裔美国人参与者更有可能高于临床截止值，并且夜间醒来和睡眠呼吸障碍症状更为频繁，但最大和总体平均腹痛严重程度较低。
FGIDs 儿童的睡眠问题很常见，与日常腹痛严重程度和疼痛干扰有关。结果表明，睡眠与疼痛的关系可能因种族/族裔群体而异。评估 FGIDs 儿童的睡眠很重要，需要进一步研究以评估潜在的机制，并评估睡眠作为该人群的潜在治疗目标。
