Department of Psychiatry, and Sackler Institute for Developmental Psychobiology, Weill Cornell Medicine, Brain and Mind Research Institute, New York, NY, USA.
Department of Neuropsychiatry, Graduate School of Medicine, Osaka City University, Osaka, Japan.
Brain Behav. 2021 Apr;11(4):e02075. doi: 10.1002/brb3.2075. Epub 2021 Feb 18.
Our previous metabolomics study showed that the plasma nervonic acid levels were higher in patients with major depressive disorder (MDD) than those in healthy controls and patients with bipolar disorder (BD). To examine whether the nervonic acid levels differ in the central nervous system, we investigated the levels in the cerebrospinal fluid (CSF) of patients with MDD, BD, and healthy controls.
Nervonic acid levels in CSF were measured by gas chromatography time-of-flight mass spectrometry. The participants included 30 patients with MDD, 30 patients with BD, and 30 healthy controls.
In contrast to our previous study, no significant differences were found in the nervonic acid level in the CSF among the patients with MDD, BD, and the healthy controls. Though no significant state-dependent changes were found among the three groups, we did observe a significant negative correlation between the nervonic acid levels and depressive symptoms in the depressive state of patients with MDD and BD (r = -0.38, p = .046). Further, a significant positive correlation was found between the nervonic acid levels and manic symptoms in the manic state of patients with BD (r = 0.79, p = .031).
The nervonic acid levels in the CSF did not differ among the patients with MDD, BD, and the healthy controls; however, a significant negative correlation with depressive symptoms and a positive correlation with manic symptoms was observed. Thus, the nervonic acid levels in the CSF may be a candidate biomarker for mood symptoms.
我们之前的代谢组学研究表明，与健康对照组和双相情感障碍（BD）患者相比，重度抑郁症（MDD）患者的血浆神经酸水平更高。为了检查神经酸水平是否在中枢神经系统中存在差异，我们研究了 MDD、BD 和健康对照组患者的脑脊液（CSF）中的神经酸水平。
采用气相色谱-飞行时间质谱法测定 CSF 中神经酸水平。参与者包括 30 名 MDD 患者、30 名 BD 患者和 30 名健康对照者。
与我们之前的研究不同，MDD、BD 患者和健康对照组之间 CSF 中的神经酸水平没有显著差异。尽管三组之间没有发现显著的状态依赖性变化，但我们确实观察到 MDD 和 BD 患者抑郁状态下神经酸水平与抑郁症状之间存在显著负相关（r=-0.38，p=0.046）。此外，还发现 BD 患者躁狂状态下神经酸水平与躁狂症状之间存在显著正相关（r=0.79，p=0.031）。
MDD、BD 患者和健康对照组之间 CSF 中的神经酸水平没有差异；然而，观察到与抑郁症状呈显著负相关，与躁狂症状呈显著正相关。因此，CSF 中的神经酸水平可能是情绪症状的候选生物标志物。
