MMWR Morb Mortal Wkly Rep. 2021 Feb 19;70(7):236-239. doi: 10.15585/mmwr.mm7007a2.
Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease with manifestations that vary widely in severity. Although minority populations are at higher risk for SLE and have more severe outcomes (1), population-based estimates of mortality by race and ethnicity are often lacking, particularly for Asian and Hispanic/Latino persons. Among 812 patients in the California Lupus Surveillance Project (CLSP) during 2007-2009 (2,3), who were matched to the 2007-2017 National Death Index (NDI), 16.6% had died by 2017. This proportion included persons of White (14.4%), Black (25%), Asian (15.3%), and Hispanic/Latino (15.5%) race/ethnicity. Standardized mortality ratios (SMRs) of observed-to-expected deaths among persons with SLE within each racial/ethnic group were 2.3, 2.0, 3.8, and 3.9, respectively. These findings provide the first population-based estimates of mortality among Asian and Hispanic/Latino persons with SLE. Coordination of robust care models between primary care providers and rheumatologists could ensure that persons with SLE receive a timely diagnosis and appropriate treatments that might help address SLE-associated mortality.
系统性红斑狼疮（SLE）是一种多系统自身免疫性疾病，其临床表现的严重程度差异很大。尽管少数人群患 SLE 的风险更高，且结局更差（1），但种族和民族的死亡率的基于人群的估计数据往往缺乏，尤其是针对亚裔和西班牙裔/拉丁裔人群。在 2007 年至 2009 年期间加利福尼亚狼疮监测项目（CLSP）的 812 名患者（2,3）中，与 2007 年至 2017 年国家死亡指数（NDI）相匹配的患者中，有 16.6%在 2017 年之前死亡。这一比例包括白人（14.4%）、黑人（25%）、亚裔（15.3%）和西班牙裔/拉丁裔（15.5%）人群。在每个种族/族裔群体中，SLE 患者的实际死亡人数与预期死亡人数的标准化死亡率（SMR）分别为 2.3、2.0、3.8 和 3.9。这些发现提供了首个关于亚裔和西班牙裔/拉丁裔 SLE 患者死亡率的基于人群的估计数据。初级保健提供者和风湿病学家之间协调强有力的护理模式，可以确保 SLE 患者及时得到诊断并接受适当的治疗，这可能有助于解决与 SLE 相关的死亡率问题。
