Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom.
Front Cell Infect Microbiol. 2021 Feb 3;10:607704. doi: 10.3389/fcimb.2020.607704. eCollection 2020.
is the leading cause of bacterial foodborne gastroenteritis world wide and represents a major public health concern. Over the past two decades, significant progress in functional genomics, proteomics, enzymatic-based virulence profiling (EBVP), and the cellular biology of have improved our basic understanding of this important pathogen. We review key advances in our understanding of the multitude of emerging virulence factors that influence the outcome of -mediated infections. We highlight, the spatial and temporal dynamics of factors that promote to sense, adapt and survive in multiple hosts. Finally, we propose cohesive research directions to obtain a comprehensive understanding of virulence mechanisms.
是世界范围内细菌性食源性胃肠炎的主要原因，也是一个主要的公共卫生关注点。在过去的二十年中，功能基因组学、蛋白质组学、基于酶的毒力分析（EBVP）和的细胞生物学的显著进展，提高了我们对这种重要病原体的基本认识。我们回顾了在理解影响介导感染结果的众多新兴毒力因子方面的重要进展。我们强调了促进在多个宿主中感知、适应和生存的因素的时空动态。最后，我们提出了有凝聚力的研究方向，以全面了解的毒力机制。
