Gu Yian, Guo Jing, Moshfegh Alanna J
Taub Institute for Research in Alzheimer's Disease and the Aging Brain Columbia University New York New York USA.
Department of Neurology Vagelos College of Physicians and Surgeons Columbia University New York New York USA.
Alzheimers Dement (N Y). 2021 Feb 14;7(1):e12128. doi: 10.1002/trc2.12128. eCollection 2021.
It is unclear whether the association between Mediterranean-type Diet (MeDi) and cognition is similar across different racial/ethnic groups or between women and men.
The current study included 2435 participants (≥60 years of age) of the National Health and Nutrition Examination Survey (NHANES) 2011-2014. Linear regression models were applied to examine the association between diet and cognition, adjusted for multiple demographic variables. Interaction between MeDi and race/ethnicity (non-Hispanic White, non-Hispanic Black, Hispanic, other), and between MeDi and gender, were examined, followed by stratified analyses.
One score increase in MeDi was associated with 0.039 (95%confidence interval [CI] = 0.016-0.062) higher global cognitive z-score. Significant associations between MeDi and global cognition and between MeDi and immediate recall were found in the non-Hispanic Whites only (-interaction = 0.057 and 0.059, respectively). MeDi was associated with increased score of animal fluency score in men but not in women (-interaction = 0.082).
The positive association between MeDi and cognition might be dependent on race/ethnicity and gender.
尚不清楚地中海式饮食（MeDi）与认知之间的关联在不同种族/族裔群体之间或男女之间是否相似。
本研究纳入了2011 - 2014年美国国家健康与营养检查调查（NHANES）中的2435名参与者（年龄≥60岁）。应用线性回归模型来检验饮食与认知之间的关联，并对多个人口统计学变量进行了调整。研究了MeDi与种族/族裔（非西班牙裔白人、非西班牙裔黑人、西班牙裔、其他）之间以及MeDi与性别之间的相互作用，随后进行了分层分析。
MeDi得分每增加1分，总体认知z得分就会高出0.039（95%置信区间[CI]=0.016 - 0.062）。仅在非西班牙裔白人中发现MeDi与总体认知以及MeDi与即时回忆之间存在显著关联（相互作用分别为0.057和0.059）。MeDi与男性的动物流畅性得分增加相关，但与女性无关（相互作用=0.082）。
MeDi与认知之间的正相关可能取决于种族/族裔和性别。
