Sousa Bryer C, Massar Christopher J, Gleason Matthew A, Cote Danielle L
Materials Science and Engineering Program, Department of Mechanical Engineering, Worcester Polytechnic Institute, 100 Institute Road, Worcester, MA, 01609-2280, USA.
J Biol Eng. 2021 Feb 24;15(1):8. doi: 10.1186/s13036-021-00256-7.
In this literature review, the antipathogenic properties and contact-mediated antibacterial and antiviral performance of copper cold spray surfaces are assessed and compared with alternative antimicrobial materials that are able to kill and/or inactivate infectious agents via direct contact. Discussion is also provided concerning the suitability of copper cold spray material consolidations as biocidal and viricidal surfaces that retain long-term functionality as a preventative measure against fomite transmission of pathogenic agents and hospital-acquired infections from contaminated high-touch surfaces. Numerable alternative antimicrobial coatings and surfaces that do not rely upon the oligodynamic action of copper are detailed. Given the ongoing need for recognition of said alternative antimicrobial materials by authoritative agencies, such as the U.S. Environmental Protection Agency, the relevant literature on non-copper-based antipathogenic coatings and surfaces are then described. Furthermore, a wide-ranging take on antipathogenic copper cold spray coatings are provided and consideration is given to the distinctive grain-boundary mediated copper ion diffusion pathways found in optimizable, highly deformed, copper cold spray material consolidations that enable pathogen inactivation on surfaces from direct contact. To conclude this literature review, analysis of how copper cold spray coatings can be employed as a preventative measure against COVID-19 was also presented in light of on-going debates surrounding SARS-CoV-2's non-primary, but non-negligible, secondary transmission pathway, and also presented in conjunction with the inevitability that future pathogens, which will be responsible for forthcoming global pandemics, may spread even more readily via fomite pathways too.
在这篇文献综述中,评估了铜冷喷涂表面的抗病原特性以及接触介导的抗菌和抗病毒性能,并将其与能够通过直接接触杀死和/或灭活感染因子的其他抗菌材料进行了比较。还讨论了铜冷喷涂材料固结物作为具有长期功能的杀菌和杀病毒表面的适用性,以此作为预防病原体通过污染物传播以及医院高接触表面获得性感染的措施。详细介绍了许多不依赖铜的微动力作用的替代抗菌涂层和表面。鉴于美国环境保护局等权威机构对上述替代抗菌材料的认可需求持续存在,随后描述了关于非铜基抗病原涂层和表面的相关文献。此外,还对广泛的抗病原铜冷喷涂涂层进行了探讨,并考虑了在可优化的、高度变形的铜冷喷涂材料固结物中发现的独特的晶界介导铜离子扩散途径,这些途径能够使表面通过直接接触实现病原体灭活。为总结这篇文献综述,鉴于围绕严重急性呼吸综合征冠状病毒2(SARS-CoV-2)非主要但不可忽视的二次传播途径的持续争论,还介绍了如何将铜冷喷涂涂层用作预防2019冠状病毒病(COVID-19)的措施,并且结合未来可能导致全球大流行的病原体可能更容易通过污染物途径传播的必然性进行了阐述。