Centre of Excellence in Severe Asthma and Priority Research Centre for Healthy Lungs, University of Newcastle, University Drive, Callaghan, NSW, 2308, Australia.
Department of Respiratory and Sleep Medicine, John Hunter Hospital, New Lambton Heights, NSW, Australia.
BMC Pulm Med. 2021 Feb 27;21(1):71. doi: 10.1186/s12890-021-01436-3.
Physical inactivity is common in severe asthma and associated with poor health outcomes. New approaches are needed to address physical inactivity in this group.
To examine whether yoga and mindfulness improves health-related quality of life (HRQoL) compared with a minimal active control group and collect feasibility data to inform future studies.
Over 12-weeks, adults with severe asthma were recruited. Participants were randomised 2:1 to parallel yoga or control groups. All participants received an activity tracker. The yoga group received tailored group classes twice a week for 16-weeks with a qualified yoga instructor. The control group set activity goals with a research officer and received eight progress calls. Outcomes were assessed at 16-weeks. Primary outcome was St George's Respiratory Questionnaire (SGRQ). Secondary outcomes included asthma control, physical activity, breathlessness, and inflammation. Face-to-face qualitative interviews were conducted to determine acceptability.
There were 15 participants randomised to yoga (mean 67 years; 60% female) and 9 to control (68 years; 56% female). Planned comparisons indicated the yoga group had greater SGRQ improvement than the control group. There was little change in secondary outcomes. Moderate-vigorous activity increased substantially in the control group. Participants found the intervention acceptable; key barriers and facilitators were social connection, the setting, addressing breathing and asthma symptoms, changing their mindset, and the intersection of different elements.
A yoga and mindfulness intervention was feasible, acceptable to patients and improved HRQoL. The findings will inform design of much needed future research into physical activity interventions for severe asthma. World Health Organization International Clinical Trials Registry Platform The study was registered under the Australian New Zealand Clinical Trials Registry (ANZCTR) on the 26th of November 2018, Trial ID ACTRN12618001914257.
在严重哮喘患者中，身体活动不足很常见，并且与不良健康结局相关。需要新的方法来解决这一群体的身体活动不足问题。
研究瑜伽和正念是否比最低限度的积极对照组更能改善与健康相关的生活质量（HRQoL），并收集可行性数据以指导未来的研究。
在 12 周内，招募患有严重哮喘的成年人。参与者按 2:1 的比例随机分为瑜伽组或对照组。所有参与者都佩戴活动追踪器。瑜伽组在 16 周内每周接受两次由合格瑜伽教练教授的小组课程。对照组与研究人员一起设定活动目标，并接受 8 次进度电话。在 16 周时评估结果。主要结果是圣乔治呼吸问卷（SGRQ）。次要结果包括哮喘控制、身体活动、呼吸困难和炎症。进行面对面的定性访谈以确定可接受性。
共有 15 名参与者被随机分配到瑜伽组（平均年龄 67 岁；60%为女性），9 名参与者被分配到对照组（平均年龄 68 岁；56%为女性）。计划比较表明，瑜伽组的 SGRQ 改善程度大于对照组。次要结果变化不大。对照组的中高强度活动显著增加。参与者认为该干预措施是可以接受的；主要障碍和促进因素是社交联系、环境、解决呼吸和哮喘症状、改变思维模式以及不同元素的交叉。
瑜伽和正念干预是可行的，患者易于接受，并且可以改善 HRQoL。研究结果将为未来严重哮喘患者的身体活动干预研究提供信息。世界卫生组织国际临床试验注册平台。该研究于 2018 年 11 月 26 日在澳大利亚新西兰临床试验注册处（ANZCTR）注册，试验编号为 ACTRN12618001914257。
