Pitale Unnati, Pal Pritish Chandra, Thakare Gauri, Verma Manish, Dhakad Shikha, Pandey Rohit
Department of Periodontics, Modern Dental College and Research Centre, Indore, Madhya Pradesh, India.
Department of Microbiology, Indira Gandhi Government Medical College and Mayo Hospital, Nagpur, Maharashtra, India.
J Indian Soc Periodontol. 2021 Jan-Feb;25(1):22-28. doi: 10.4103/jisp.jisp_19_20. Epub 2021 Jan 7.
Reconstruction of interdental papillae (IDP) is among the most difficult periodontal therapy. Papillary recession is multifactorial, and several surgical, nonsurgical, and minimally invasive techniques have been suggested. The purpose of this study was to evaluate the clinical application of injectable hyaluronic acid (HA) gel for the reconstruction of IDP in Nordland and Tarnow's Class I and II papillary recession cases.
In the present clinical trial, 7 patients (2 males, 5 females) with 25 defects were selected. A volume of 0.2 ml HA gel was injected at the respective areas and massaged for 2-3 min. Photographs were obtained, and the assessment of the data was performed clinically (CP-GM, interproximal width [IPW]) and by Image analysis software (black triangle height [BTH], black triangle width [BTW]). Comparison of mean values was performed using the analysis of variance, followed by Bonferroni test. Value of ≤ 0.05 was considered statistically significant.
Application of HA gel for the reconstruction of IDP was successful in 6 months. CP-GM, BTH, IPW, and BTW showed a statistically significant difference from baseline to 3 and 6 months interval ( = 0.01). Bonferroni test for CP-GM, BTH, BTW, and IPW revealed a statistically significant difference from baseline to 3 months ( ≤ 0.05) and 6 months ( ≤ 0.05) and a nonsignificant difference at 3-6 months ( ≥ 0.05).
Injectable HA gel is a promising minimally invasive therapy for enhancing papillary esthetics.
牙间乳头（IDP）重建是最难的牙周治疗之一。乳头退缩是多因素导致的，已经提出了多种手术、非手术和微创技术。本研究的目的是评估可注射透明质酸（HA）凝胶在诺德兰和塔尔诺夫I类和II类乳头退缩病例中重建IDP的临床应用。
在本临床试验中，选择了7例患者（2例男性，5例女性），共25处缺损。在相应区域注射0.2 ml HA凝胶并按摩2 - 3分钟。拍摄照片，并通过临床（CP - GM、邻间宽度[IPW]）和图像分析软件（黑三角高度[BTH]、黑三角宽度[BTW]）进行数据评估。使用方差分析进行平均值比较，随后进行邦费罗尼检验。≤0.05的值被认为具有统计学意义。
HA凝胶用于重建IDP在6个月时取得成功。CP - GM、BTH、IPW和BTW从基线到3个月和6个月时显示出统计学上的显著差异（ = 0.01）。对CP - GM、BTH、BTW和IPW进行的邦费罗尼检验显示，从基线到3个月（≤0.05）和6个月（≤0.05）有统计学显著差异，而在3 - 6个月时有非显著差异（≥0.05）。
可注射HA凝胶是一种有前景且微创的改善乳头美观的治疗方法。
