MM School of Pharmacy, Maharishi Markandeshwar University, Sadopur, Ambala, Haryana 134007, India.
Maharishi Dayanand University, Rohtak, Haryana 124001, India.
Biomed Res Int. 2021 Feb 15;2021:8844030. doi: 10.1155/2021/8844030. eCollection 2021.
Dendrimers are nanosized, symmetrical molecules in which a small atom or group of atoms is surrounded by the symmetric branches known as dendrons. The structure of dendrimers possesses the greatest impact on their physical and chemical properties. They grow outwards from the core-shell which further reacts with monomers having one reactive or two dormant molecules. Dendrimers' unique characteristics such as hyperbranching, well-defined spherical structure, and high compatibility with the biological systems are responsible for their wide range of applications including medical and biomedical areas. Particularly, the dendrimers' three-dimensional structure can incorporate a wide variety of drugs to form biologically active drug conjugates. In this review, we focus on the synthesis, mechanism of drug encapsulations in dendrimers, and their wide applications in drug delivery.
树状高分子是纳米级的、对称的分子，其中一个小原子或一组原子被称为树枝状大分子的对称分支所包围。树状高分子的结构对其物理和化学性质有最大的影响。它们从核壳向外生长，然后进一步与具有一个活性或两个休眠分子的单体反应。树状高分子的独特特性，如超支化、明确的球形结构和与生物系统的高度相容性，是其在包括医学和生物医学领域在内的广泛应用的原因。特别是，树状高分子的三维结构可以结合多种药物形成具有生物活性的药物偶联物。在这篇综述中，我们重点介绍了树状高分子的合成、药物包封机制及其在药物传递中的广泛应用。
