Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States of America.
Research Office, San Ignacio University Hospital, Bogota, Colombia.
PLoS One. 2021 Mar 4;16(3):e0246987. doi: 10.1371/journal.pone.0246987. eCollection 2021.
Contact tracing is a crucial part of the public health surveillance toolkit. However, it is labor-intensive and costly to carry it out. Some countries have faced challenges implementing contact tracing, and no impact evaluations using empirical data have assessed its impact on COVID-19 mortality. This study assesses the impact of contact tracing in a middle-income country, providing data to support the expansion and optimization of contact tracing strategies to improve infection control.
We obtained publicly available data on all confirmed COVID-19 cases in Colombia between March 2 and June 16, 2020. (N = 54,931 cases over 135 days of observation). As suggested by WHO guidelines, we proxied contact tracing performance as the proportion of cases identified through contact tracing out of all cases identified. We calculated the daily proportion of cases identified through contact tracing across 37 geographical units (32 departments and five districts). Further, we used a sequential log-log fixed-effects model to estimate the 21-days, 28-days, 42-days, and 56-days lagged impact of the proportion of cases identified through contact tracing on daily COVID-19 mortality. Both the proportion of cases identified through contact tracing and the daily number of COVID-19 deaths are smoothed using 7-day moving averages. Models control for the prevalence of active cases, second-degree polynomials, and mobility indices. Robustness checks to include supply-side variables were performed.
We found that a 10 percent increase in the proportion of cases identified through contact tracing is related to COVID-19 mortality reductions between 0.8% and 3.4%. Our models explain between 47%-70% of the variance in mortality. Results are robust to changes of specification and inclusion of supply-side variables.
Contact tracing is instrumental in containing infectious diseases. Its prioritization as a surveillance strategy will substantially impact reducing deaths while minimizing the impact on the fragile economic systems of lower and middle-income countries. This study provides lessons for other LMIC.
接触者追踪是公共卫生监测工具包的重要组成部分。然而,实施接触者追踪需要大量的人力和财力。一些国家在实施接触者追踪方面面临挑战,并且没有使用经验数据评估其对 COVID-19 死亡率的影响的影响评估。本研究评估了中低收入国家接触者追踪的影响,提供了支持扩大和优化接触者追踪策略以改善感染控制的数据。
我们获得了哥伦比亚 2020 年 3 月 2 日至 6 月 16 日期间所有确诊 COVID-19 病例的公开数据(观察期内共 135 天,共 54931 例病例)。根据世界卫生组织的指导方针,我们将接触者追踪的表现代理为通过接触者追踪发现的病例数占所有发现病例数的比例。我们计算了 37 个地理单位(32 个部门和 5 个区)中通过接触者追踪发现的病例的每日比例。此外,我们使用序贯对数固定效应模型来估计通过接触者追踪发现的病例比例对每日 COVID-19 死亡率的 21 天、28 天、42 天和 56 天滞后影响。通过接触者追踪发现的病例比例和每日 COVID-19 死亡人数均使用 7 天移动平均值进行平滑处理。模型控制了活跃病例的流行率、二次多项式和流动性指数。进行了包括供应方变量的稳健性检查。
我们发现,通过接触者追踪发现的病例比例增加 10%,与 COVID-19 死亡率降低 0.8%至 3.4%相关。我们的模型解释了死亡率变化的 47%-70%。结果在规范变更和包括供应方变量时具有稳健性。
接触者追踪对于控制传染病至关重要。将其作为监测策略进行优先排序将大大降低死亡率,同时将对中下收入国家脆弱的经济系统的影响降至最低。本研究为其他中低收入国家提供了经验教训。