Departamento de Medicina Preventiva y Salud Pública, Facultad de Medicina, Universidad de Granada, 18071 Granada, Spain.
Instituto de Investigación Biosanitaria de Granada, 18012 Granada, Spain.
Nutrients. 2021 Oct 17;13(10):3627. doi: 10.3390/nu13103627.
Intestinal microbiota has been shown to be a potential determining factor in the development of obesity. The objective of this systematic review is to collect and learn, based on the latest available evidence, the effect of the use of probiotics and synbiotics in randomized clinical trials on weight loss in people with overweight and obesity. A search for articles was carried out in PubMed, Web of science and Scopus until September 2021, using search strategies that included the terms "obesity", "overweight", "probiotic", "synbiotic", "", "" and "weight loss". Of the 185 articles found, only 27 complied with the selection criteria and were analyzed in the review, of which 23 observed positive effects on weight loss. The intake of probiotics or synbiotics could lead to significant weight reductions, either maintaining habitual lifestyle habits or in combination with energy restriction and/or increased physical activity for an average of 12 weeks. Specific strains belonging to the genus and were the most used and those that showed the best results in reducing body weight. Both probiotics and synbiotics have the potential to help in weight loss in overweight and obese populations.
肠道微生物群已被证明是肥胖发展的一个潜在决定因素。本系统评价的目的是收集并根据最新的可用证据，了解在超重和肥胖人群中使用益生菌和合生菌的随机临床试验对体重减轻的影响。在 2021 年 9 月之前，我们在 PubMed、Web of science 和 Scopus 中进行了文章搜索，使用的搜索策略包括“肥胖”、“超重”、“益生菌”、“合生菌”、“减肥”和“体重减轻”等术语。在 185 篇文章中，只有 27 篇符合选择标准，并在综述中进行了分析，其中 23 篇观察到对体重减轻有积极影响。摄入益生菌或合生菌可能会导致体重显著减轻，无论是在维持习惯性生活方式习惯的情况下，还是在与能量限制和/或增加体力活动相结合的情况下，平均持续 12 周。属于 和 属的特定菌株是最常用的，并且在降低体重方面显示出最好的效果。益生菌和合生菌都有可能帮助超重和肥胖人群减轻体重。
