Marcu Loredana G, Bezak Eva, Peukert Dylan D, Wilson Puthenparampil
Faculty of Informatics & Science, Department of Physics, University of Oradea, 410087 Oradea, Romania.
Cancer Research Institute and School of Health Sciences, University of South Australia, Adelaide, SA 5001, Australia.
Biomedicines. 2021 Feb 11;9(2):181. doi: 10.3390/biomedicines9020181.
FLASH radiotherapy, or the administration of ultra-high dose rate radiotherapy, is a new radiation delivery method that aims to widen the therapeutic window in radiotherapy. Thus far, most in vitro and in vivo results show a real potential of FLASH to offer superior normal tissue sparing compared to conventionally delivered radiation. While there are several postulations behind the differential behaviour among normal and cancer cells under FLASH, the full spectra of radiobiological mechanisms are yet to be clarified. Currently the number of devices delivering FLASH dose rate is few and is mainly limited to experimental and modified linear accelerators. Nevertheless, FLASH research is increasing with new developments in all the main areas: radiobiology, technology and clinical research. This paper presents the current status of FLASH radiotherapy with the aforementioned aspects in mind, but also to highlight the existing challenges and future prospects to overcome them.
闪疗，即超高剂量率放疗的应用，是一种旨在扩大放疗治疗窗的新型放疗方式。迄今为止，大多数体外和体内研究结果表明，与传统放疗相比，闪疗在保护正常组织方面具有显著潜力。虽然在闪疗条件下正常细胞和癌细胞表现出不同行为背后有多种假设，但放射生物学机制的全貌仍有待阐明。目前，能够提供闪疗剂量率的设备数量很少，主要限于实验性和经过改装的直线加速器。尽管如此，随着放射生物学、技术和临床研究等所有主要领域的新进展，闪疗研究正在不断增加。本文在考虑上述方面的基础上介绍了闪疗的现状，同时也强调了现有挑战以及克服这些挑战的未来前景。
