用于促进再生医学发展的生物活性高分子材料
Bioactive Polymeric Materials for the Advancement of Regenerative Medicine.
作者信息
Iovene Anthony, Zhao Yuwen, Wang Shue, Amoako Kagya
机构信息
Biomedical Engineering Graduate Program, Tagliatela College of Engineering, Biomedical Engineering Faculty, University of New Haven, 300 Boston Post Rd., West Haven, CT 06516, USA.
Department of Mechanical, Industrial and Biomedical Engineering, Tagliatela College of Engineering, Biomedical Engineering Faculty, University of New Haven, 300 Boston Post Rd., West Haven, CT 06516, USA.
出版信息
J Funct Biomater. 2021 Feb 20;12(1):14. doi: 10.3390/jfb12010014.
Biopolymers are widely accepted natural materials in regenerative medicine, and further development of their bioactivities and discoveries on their composition/function relationships could greatly advance the field. However, a concise insight on commonly investigated biopolymers, their current applications and outlook of their modifications for multibioactivity are scarce. This review bridges this gap for professionals and especially freshmen in the field who are also interested in modification methods not yet in commercial use. A series of polymeric materials in research and development uses are presented as well as challenges that limit their efficacy in tissue regeneration are discussed. Finally, their roles in the regeneration of select tissues including the skin, bone, cartilage, and tendon are highlighted along with modifiable biopolymer moieties for different bioactivities.
生物聚合物是再生医学中广泛认可的天然材料，其生物活性的进一步发展以及对其组成/功能关系的发现能够极大地推动该领域的进步。然而，目前对于常见研究的生物聚合物、它们的当前应用以及用于多生物活性修饰的前景缺乏简洁的见解。这篇综述为该领域的专业人士，尤其是对尚未商业化的修饰方法感兴趣的新手填补了这一空白。文中介绍了一系列处于研发阶段的聚合材料，并讨论了限制其在组织再生中功效的挑战。最后，强调了它们在包括皮肤、骨骼、软骨和肌腱在内的特定组织再生中的作用，以及具有不同生物活性的可修饰生物聚合物部分。
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