• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

肝细胞癌治疗结果预测中机器学习的最新进展:我们应该了解什么?

Current updates in machine learning in the prediction of therapeutic outcome of hepatocellular carcinoma: what should we know?

作者信息

Zou Zhi-Min, Chang De-Hua, Liu Hui, Xiao Yu-Dong

机构信息

Department of Radiology, The Second Xiangya Hospital of Central South University, No.139 Middle Renmin Road, Changsha, 410011, China.

Department of Diagnostic and Interventional Radiology, University Hospital Heidelberg, 69120, Heidelberg, Germany.

出版信息

Insights Imaging. 2021 Mar 6;12(1):31. doi: 10.1186/s13244-021-00977-9.

DOI:10.1186/s13244-021-00977-9
PMID:33675433
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7936998/
Abstract

With the development of machine learning (ML) algorithms, a growing number of predictive models have been established for predicting the therapeutic outcome of patients with hepatocellular carcinoma (HCC) after various treatment modalities. By using the different combinations of clinical and radiological variables, ML algorithms can simulate human learning to detect hidden patterns within the data and play a critical role in artificial intelligence techniques. Compared to traditional statistical methods, ML methods have greater predictive effects. ML algorithms are widely applied in nearly all steps of model establishment, such as imaging feature extraction, predictive factor classification, and model development. Therefore, this review presents the literature pertaining to ML algorithms and aims to summarize the strengths and limitations of ML, as well as its potential value in prognostic prediction, after various treatment modalities for HCC.

摘要

随着机器学习(ML)算法的发展,已经建立了越来越多的预测模型,用于预测肝细胞癌(HCC)患者在接受各种治疗方式后的治疗结果。通过使用临床和放射学变量的不同组合,ML算法可以模拟人类学习以检测数据中的隐藏模式,并在人工智能技术中发挥关键作用。与传统统计方法相比,ML方法具有更强的预测效果。ML算法广泛应用于模型建立的几乎所有步骤,如图像特征提取、预测因子分类和模型开发。因此,本综述介绍了与ML算法相关的文献,旨在总结ML的优势和局限性,以及其在HCC各种治疗方式后的预后预测中的潜在价值。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c4ec/7936998/58627baf2bfb/13244_2021_977_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c4ec/7936998/1389811210db/13244_2021_977_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c4ec/7936998/5804cea7c2b2/13244_2021_977_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c4ec/7936998/13ab167f88bf/13244_2021_977_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c4ec/7936998/7bf3b693c80d/13244_2021_977_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c4ec/7936998/58627baf2bfb/13244_2021_977_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c4ec/7936998/1389811210db/13244_2021_977_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c4ec/7936998/5804cea7c2b2/13244_2021_977_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c4ec/7936998/13ab167f88bf/13244_2021_977_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c4ec/7936998/7bf3b693c80d/13244_2021_977_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c4ec/7936998/58627baf2bfb/13244_2021_977_Fig5_HTML.jpg

相似文献

1
Current updates in machine learning in the prediction of therapeutic outcome of hepatocellular carcinoma: what should we know?肝细胞癌治疗结果预测中机器学习的最新进展:我们应该了解什么?
Insights Imaging. 2021 Mar 6;12(1):31. doi: 10.1186/s13244-021-00977-9.
2
Machine-learning analysis of contrast-enhanced CT radiomics predicts recurrence of hepatocellular carcinoma after resection: A multi-institutional study.基于增强 CT 影像组学的机器学习分析预测肝癌切除术后复发:多中心研究。
EBioMedicine. 2019 Dec;50:156-165. doi: 10.1016/j.ebiom.2019.10.057. Epub 2019 Nov 15.
3
Application of artificial intelligence in the diagnosis and treatment of hepatocellular carcinoma: A review.人工智能在肝细胞癌诊疗中的应用:综述
World J Gastroenterol. 2020 Oct 7;26(37):5617-5628. doi: 10.3748/wjg.v26.i37.5617.
4
Applying Machine Learning in Liver Disease and Transplantation: A Comprehensive Review.应用机器学习于肝脏疾病和移植:全面综述。
Hepatology. 2020 Mar;71(3):1093-1105. doi: 10.1002/hep.31103. Epub 2020 Mar 6.
5
Preoperative prediction for pathological grade of hepatocellular carcinoma via machine learning-based radiomics.基于机器学习的放射组学术前预测肝细胞癌的病理分级。
Eur Radiol. 2020 Dec;30(12):6924-6932. doi: 10.1007/s00330-020-07056-5. Epub 2020 Jul 22.
6
Novel Feature Selection for Artificial Intelligence Using Item Response Theory for Mortality Prediction.基于项目反应理论的人工智能新型特征选择用于死亡率预测
Annu Int Conf IEEE Eng Med Biol Soc. 2020 Jul;2020:5729-5732. doi: 10.1109/EMBC44109.2020.9175403.
7
Machine learning in cardiovascular medicine: are we there yet?机器学习在心血管医学中的应用:我们是否已经实现?
Heart. 2018 Jul;104(14):1156-1164. doi: 10.1136/heartjnl-2017-311198. Epub 2018 Jan 19.
8
Deep learning in hepatocellular carcinoma: Current status and future perspectives.肝细胞癌中的深度学习:现状与未来展望。
World J Hepatol. 2021 Dec 27;13(12):2039-2051. doi: 10.4254/wjh.v13.i12.2039.
9
Toward analyzing and synthesizing previous research in early prediction of cardiac arrest using machine learning based on a multi-layered integrative framework.针对基于多层综合框架的机器学习在心脏骤停早期预测中的分析和综合既往研究。
J Biomed Inform. 2018 Dec;88:70-89. doi: 10.1016/j.jbi.2018.10.008. Epub 2018 Oct 30.
10
Predicting Treatment Response to Intra-arterial Therapies for Hepatocellular Carcinoma with the Use of Supervised Machine Learning-An Artificial Intelligence Concept.运用监督式机器学习——一种人工智能概念预测肝细胞癌动脉内治疗的反应
J Vasc Interv Radiol. 2018 Jun;29(6):850-857.e1. doi: 10.1016/j.jvir.2018.01.769. Epub 2018 Mar 14.

引用本文的文献

1
Clinical and Imaging-Based Prognostic Models for Recurrence and Local Tumor Progression Following Thermal Ablation of Hepatocellular Carcinoma: A Systematic Review.肝细胞癌热消融术后复发和局部肿瘤进展的基于临床和影像的预后模型:一项系统评价
Cancers (Basel). 2025 Aug 14;17(16):2656. doi: 10.3390/cancers17162656.
2
Machine learning analysis of survival outcomes in breast cancer patients treated with chemotherapy, hormone therapy, surgery, and radiotherapy.对接受化疗、激素治疗、手术和放疗的乳腺癌患者生存结果的机器学习分析。
Sci Rep. 2025 Jul 10;15(1):24981. doi: 10.1038/s41598-025-97763-0.
3
Artificial intelligence to predict hepatocellular carcinoma risk in cirrhosis.

本文引用的文献

1
Novel Model to Predict HCC Recurrence after Liver Transplantation Obtained Using Deep Learning: A Multicenter Study.使用深度学习获得的预测肝移植后肝癌复发的新型模型:一项多中心研究
Cancers (Basel). 2020 Sep 29;12(10):2791. doi: 10.3390/cancers12102791.
2
Prediction of early recurrence of hepatocellular carcinoma after resection using digital pathology images assessed by machine learning.利用机器学习评估数字病理学图像预测肝癌切除术后早期复发。
Mod Pathol. 2021 Feb;34(2):417-425. doi: 10.1038/s41379-020-00671-z. Epub 2020 Sep 18.
3
Artificial neural network model for preoperative prediction of severe liver failure after hemihepatectomy in patients with hepatocellular carcinoma.
人工智能预测肝硬化患者肝细胞癌风险
World J Gastrointest Oncol. 2025 Jun 15;17(6):107414. doi: 10.4251/wjgo.v17.i6.107414.
4
Modeling the compressive strength behavior of concrete reinforced with basalt fiber.玄武岩纤维增强混凝土抗压强度性能建模
Sci Rep. 2025 Apr 3;15(1):11493. doi: 10.1038/s41598-025-96343-6.
5
Modeling suction of unsaturated granular soil treated with biochar in plant microbial fuel cell bioelectricity system.植物微生物燃料电池生物电系统中生物炭处理的非饱和粒状土壤吸力建模。
Sci Rep. 2025 Jan 9;15(1):1439. doi: 10.1038/s41598-025-85701-z.
6
Artificial intelligence: clinical applications and future advancement in gastrointestinal cancers.人工智能:胃肠道癌症的临床应用及未来进展
Front Artif Intell. 2024 Dec 20;7:1446693. doi: 10.3389/frai.2024.1446693. eCollection 2024.
7
Research progress on machine algorithm prediction of liver cancer prognosis after intervention therapy.肝癌介入治疗后预后的机器算法预测研究进展
Am J Cancer Res. 2024 Sep 25;14(9):4580-4596. doi: 10.62347/BEAO1926. eCollection 2024.
8
Radiomics analysis of baseline computed tomography to predict oncological outcomes in patients treated for resectable colorectal cancer liver metastasis.基于基线 CT 的影像组学分析预测可切除结直肠癌肝转移患者的肿瘤学结局。
PLoS One. 2024 Sep 11;19(9):e0307815. doi: 10.1371/journal.pone.0307815. eCollection 2024.
9
Prognosis Prediction in Head and Neck Squamous Cell Carcinoma by Radiomics and Clinical Information.基于影像组学和临床信息的头颈部鳞状细胞癌预后预测
Biomedicines. 2024 Jul 24;12(8):1646. doi: 10.3390/biomedicines12081646.
10
Assessment of Albumin-Incorporating Scores at Hepatocellular Carcinoma Diagnosis Using Machine Learning Techniques: An Evaluation of Prognostic Relevance.使用机器学习技术评估肝细胞癌诊断时的白蛋白整合评分:预后相关性评估
Bioengineering (Basel). 2024 Jul 28;11(8):762. doi: 10.3390/bioengineering11080762.
基于人工智能神经网络模型的肝癌半肝切除术后发生严重肝功能衰竭的术前预测。
Surgery. 2020 Oct;168(4):643-652. doi: 10.1016/j.surg.2020.06.031. Epub 2020 Aug 11.
4
Machine learning-based development and validation of a scoring system for progression-free survival in liver cancer.基于机器学习的肝癌无进展生存期评分系统的建立和验证。
Hepatol Int. 2020 Jul;14(4):567-576. doi: 10.1007/s12072-020-10046-w. Epub 2020 Jun 18.
5
A differential risk assessment and decision model for Transarterial chemoembolization in hepatocellular carcinoma based on hepatic function.基于肝功能的肝细胞癌经动脉化疗栓塞术的差异风险评估与决策模型
BMC Cancer. 2020 Jun 1;20(1):504. doi: 10.1186/s12885-020-06975-2.
6
Comparison of Deep-Learning and Conventional Machine-Learning Methods for the Automatic Recognition of the Hepatocellular Carcinoma Areas from Ultrasound Images.深度学习与传统机器学习方法在自动识别超声图像肝癌区域的比较。
Sensors (Basel). 2020 May 29;20(11):3085. doi: 10.3390/s20113085.
7
Neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios as predictors of tumor response in hepatocellular carcinoma after DEB-TACE.中性粒细胞与淋巴细胞比值和血小板与淋巴细胞比值可预测 DEB-TACE 后肝癌患者的肿瘤反应。
Eur Radiol. 2020 Oct;30(10):5663-5673. doi: 10.1007/s00330-020-06931-5. Epub 2020 May 19.
8
A novel machine learning algorithm to predict disease free survival after resection of hepatocellular carcinoma.一种预测肝细胞癌切除术后无病生存期的新型机器学习算法。
Ann Transl Med. 2020 Apr;8(7):434. doi: 10.21037/atm.2020.04.16.
9
Role of baseline volumetric functional MRI in predicting histopathologic grade and patients' survival in hepatocellular carcinoma.基线容积功能 MRI 在预测肝细胞癌组织病理学分级和患者生存中的作用。
Eur Radiol. 2020 Jul;30(7):3748-3758. doi: 10.1007/s00330-020-06742-8. Epub 2020 Mar 6.
10
Predicting Survival After Hepatocellular Carcinoma Resection Using Deep Learning on Histological Slides.基于组织切片的深度学习预测肝细胞癌切除术后的生存情况。
Hepatology. 2020 Dec;72(6):2000-2013. doi: 10.1002/hep.31207.