Department of Nutrition, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27516, USA.
Department of Family and Consumer Sciences, College of Agriculture, University of Wyoming, Laramie, WY 82071, USA.
Soc Cogn Affect Neurosci. 2023 Feb 6;18(1). doi: 10.1093/scan/nsab018.
Identifying correlates of brain response to food cues and taste provides critical information on individual differences that may influence variability in eating behavior. However, a few studies examine how brain response changes over repeated exposures and the individual factors that are associated with these changes. Using functional magnetic resonance imaging, we examined how brain response to a palatable taste and proceeding cues changed over repeated exposures and how individual differences in weight, familial obesity risk, dietary restraint and reward responsiveness correlate with these changes. In healthy-weight adolescents (n = 154), caudate and posterior cingulate cortex (PCC) response increased with repeated cue presentations, and oral somatosensory cortex and insula response increased with repeated milkshake tastes. The magnitude of increase over exposures in the left PCC to cues was positively associated with body mass index percentile (r = 0.18, P = 0.026) and negatively associated with dietary restraint scores (r = -0.24, P = 0.003). Adolescents with familial obesity risk showed higher cue-evoked caudate response across time, compared to the low-risk group (r = 0.12, P = 0.035). Reward responsiveness positively correlated with right oral somatosensory cortex/insula response to milkshake over time (r = 0.19, P = 0.018). The results show that neural responses to food cues and taste change over time and that individual differences related to weight gain are correlated with these changes.
确定大脑对食物线索和味道的反应与个体差异相关，这些差异可能会影响进食行为的可变性。然而，只有少数研究探讨了大脑对食物线索和味道的反应如何随重复暴露而变化，以及与这些变化相关的个体因素。本研究使用功能磁共振成像技术，探讨了健康青少年（n=154）在重复呈现食物线索和味道时，大脑对美味味觉和后续线索的反应如何变化，以及体重、家族肥胖风险、饮食限制和奖赏反应性等个体差异与这些变化的相关性。结果表明，大脑对食物线索和味道的反应随时间而变化，与体重增加相关的个体差异与这些变化相关。
