Pak J Biol Sci. 2021 Jan;24(2):274-281. doi: 10.3923/pjbs.2021.274.281.
The andaliman fruits have anti-inflammatory, antioxidant activity and a strong inhibition in antitumor activity. The purpose of this study was to analyze the effect of extract andaliman on rat's kidney and liver histology induced by benzopyrene.
The rats model of cancer-induced benzopyrene. This research consists of 5 groups; K-: Control, K+: Cancer model rats, P1: A dose of 100 mg per b.wt. per day of andaliman, P2: A dose of 200 mg per b.wt. per day and P3: A dose of 400 mg kg-1 b.wt., per day for 30 days. On the 31st day, performed surgically on the subjects.
There were significant differences in the value of narrowing of the renal tubules (p<0.001), kidneys cells necrosis (p<0.01), hydrophilic degeneration (p<0.001), parenchymatous degeneration (p<0.01) and necrosis (p<0.001) in the liver after given the extract andaliman.
Andaliman methanol extract repairs the damage of the liver and kidney of rats induced by benzopyrene. Andaliman can be recommended as a drug to repair the necrosis in the liver and kidneys caused by cancer.
藤黄果实具有抗炎、抗氧化活性，并具有强烈的抗肿瘤活性抑制作用。本研究的目的是分析藤黄提取物对苯并芘诱导的大鼠肾脏和肝脏组织学的影响。
采用苯并芘诱导癌症的大鼠模型。本研究包括 5 组：K-：对照组；K+：癌症模型大鼠组；P1：每天每公斤体重 100 毫克的藤黄提取物；P2：每天每公斤体重 200 毫克；P3：每天每公斤体重 400 毫克，共 30 天。第 31 天对受试者进行手术。
藤黄提取物给药后，肾小管狭窄（p<0.001）、肾细胞坏死（p<0.01）、亲水性变性（p<0.001）、实质变性（p<0.01）和肝坏死（p<0.001）的数值存在显著差异。
藤黄甲醇提取物可修复苯并芘诱导的大鼠肝、肾损伤。藤黄可作为修复癌症引起的肝、肾坏死的药物推荐。
