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脑膜淋巴管在胶质母细胞瘤中启动肿瘤免疫。

Meningeal lymphatics prime tumor immunity in glioblastoma.

机构信息

Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

出版信息

Cancer Cell. 2021 Mar 8;39(3):304-306. doi: 10.1016/j.ccell.2021.02.012.

DOI:10.1016/j.ccell.2021.02.012
PMID:33689701
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9549925/
Abstract

The notion of the brain as an immune-privileged organ has been challenged by the discovery of functional lymphatic vessels in the meninges of the dorsal and basal skull. A study published in Nature in 2020 shows that meningeal lymphatics play an important role in the sensing of brain tumor antigens.

摘要

大脑作为免疫特权器官的概念受到了挑战,因为人们在颅背侧和颅底部脑膜中发现了功能性淋巴管。2020 年发表在《自然》杂志上的一项研究表明,脑膜淋巴管在大脑肿瘤抗原的感应中起着重要作用。

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本文引用的文献

1
Afferent Lymphatic Transport and Peripheral Tissue Immunity.淋巴液输入与外周组织免疫。
J Immunol. 2021 Jan 15;206(2):264-272. doi: 10.4049/jimmunol.2001060.
2
Meningeal lymphatic vessels regulate brain tumor drainage and immunity.脑膜淋巴管调节脑肿瘤引流和免疫。
Cell Res. 2020 Mar;30(3):229-243. doi: 10.1038/s41422-020-0287-8. Epub 2020 Feb 24.
3
Heterogeneity of response to immune checkpoint blockade in hypermutated experimental gliomas.免疫检查点阻断在高突变实验性脑胶质瘤中的反应异质性。
Nat Commun. 2020 Feb 18;11(1):931. doi: 10.1038/s41467-020-14642-0.
4
VEGF-C-driven lymphatic drainage enables immunosurveillance of brain tumours.VEGF-C 驱动的淋巴引流使脑肿瘤能够进行免疫监视。
Nature. 2020 Jan;577(7792):689-694. doi: 10.1038/s41586-019-1912-x. Epub 2020 Jan 15.
5
Neoadjuvant anti-PD-1 immunotherapy promotes a survival benefit with intratumoral and systemic immune responses in recurrent glioblastoma.新辅助抗 PD-1 免疫治疗在复发性胶质母细胞瘤中促进了肿瘤内和全身免疫应答,并带来生存获益。
Nat Med. 2019 Mar;25(3):477-486. doi: 10.1038/s41591-018-0337-7. Epub 2019 Feb 11.
6
CNS lymphatic drainage and neuroinflammation are regulated by meningeal lymphatic vasculature.中枢神经系统的淋巴引流和神经炎症受脑膜淋巴血管调节。
Nat Neurosci. 2018 Oct;21(10):1380-1391. doi: 10.1038/s41593-018-0227-9. Epub 2018 Sep 17.
7
VEGF-C sustains VEGFR2 activation under bevacizumab therapy and promotes glioblastoma maintenance.VEGF-C 在贝伐珠单抗治疗下维持 VEGFR2 激活,并促进胶质母细胞瘤的维持。
Neuro Oncol. 2018 Oct 9;20(11):1462-1474. doi: 10.1093/neuonc/noy103.
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Current state of immunotherapy for glioblastoma.胶质母细胞瘤的免疫治疗现状。
Nat Rev Clin Oncol. 2018 Jul;15(7):422-442. doi: 10.1038/s41571-018-0003-5.
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Tumor Evolution of Glioma-Intrinsic Gene Expression Subtypes Associates with Immunological Changes in the Microenvironment.胶质瘤内在基因表达亚型的肿瘤进化与微环境中的免疫变化相关。
Cancer Cell. 2018 Jan 8;33(1):152. doi: 10.1016/j.ccell.2017.12.012.
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Oncology meets immunology: the cancer-immunity cycle.肿瘤学与免疫学:癌症免疫周期。
Immunity. 2013 Jul 25;39(1):1-10. doi: 10.1016/j.immuni.2013.07.012.