Zhou Jiang, Wang Baisheng, Bin Xin, Xie Changqing, Li Bo, Liu Ousheng, Tang Zhangui
Hunan Key Laboratory of Oral Health Research & Hunan 3D Printing Engineering Research Center of Oral Care & Hunan Clinical Research Center of Oral Major Diseases and Oral Health & Xiangya Stomatological Hospital & Xiangya School of Stomatology, Central South University, Changsha, China.
Front Med (Lausanne). 2021 Feb 22;8:615417. doi: 10.3389/fmed.2021.615417. eCollection 2021.
A large number of studies in China and other countries have confirmed that circularHIPK3 (circHIPK3) plays an important role in the pathophysiological processes of various diseases. Through the action of sponge miRNA (miR), circHIPK3 regulates cell proliferation, differentiation, and migration, and plays a key role in disease processes. By referring to a large number of research reports, this article explores the specific functional role of circHIPK3 in fibrotic diseases, cancer, and other diseases. This review aims to clarify the role of circHIPK3 in disease processes in order to aid further studies into the specific pathogenesis and clinical diagnosis of various diseases and provide new ideas for treatments.
中国和其他国家的大量研究证实，环状HIPK3（circHIPK3）在多种疾病的病理生理过程中发挥着重要作用。通过海绵状微小RNA（miR）的作用，circHIPK3调节细胞增殖、分化和迁移，并在疾病过程中起关键作用。通过参考大量研究报告，本文探讨了circHIPK3在纤维化疾病、癌症和其他疾病中的具体功能作用。这篇综述旨在阐明circHIPK3在疾病过程中的作用，以有助于进一步研究各种疾病的具体发病机制和临床诊断，并为治疗提供新思路。
