Memory Clinic, Tor Vergata University, Rome, Italy -
Memory Clinic, Tor Vergata University, Rome, Italy.
Minerva Med. 2021 Aug;112(4):441-447. doi: 10.23736/S0026-4806.21.07448-6. Epub 2021 Mar 12.
Cognitive reserve is originally an epidemiological concept that encompasses individual abilities to cope with changes. It is considered the result of a balance between processes of cellular damage and repair, and its description raised much interest in predicting and preventing cognitive decline in aging and Alzheimer's disease (AD). In this study, we discussed the concept of cognitive reserve considering the recent definition of AD as a biological continuum and suggest that the protection of cognitive reserve may result from efficient synaptic plasticity mechanisms. Despite pathological changes of AD appearing very early during life, long before the onset of cognitive symptoms, different variables act together to keep repair mechanisms effective guaranteeing successful aging if environmental enrichment is maintained.
认知储备最初是一个流行病学概念，包含个体应对变化的能力。它被认为是细胞损伤和修复过程之间平衡的结果，其描述在预测和预防衰老和阿尔茨海默病（AD）认知能力下降方面引起了极大的兴趣。在这项研究中，我们考虑到 AD 最近被定义为一种生物学连续体的概念来讨论认知储备的概念，并提出认知储备的保护可能源于有效的突触可塑性机制。尽管 AD 的病理变化在生命早期很早就出现了，远早于认知症状出现之前，但如果保持环境丰富，不同的变量会共同作用，保持修复机制的有效性，从而保证成功的衰老。
