From the Student Research Committee, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
ASAIO J. 2021 Jul 1;67(7):709-720. doi: 10.1097/MAT.0000000000001356.
Choosing the material with the best regeneration potential and properties closest to that of the extracellular matrix is one of the main challenges in tissue engineering and regenerative medicine. Natural polymers, such as collagen, elastin, and cellulose, are widely used for this purpose in tissue engineering. Cellulose derived from bacteria has excellent mechanical properties, high hydrophilicity, crystallinity, and a high degree of polymerization and, therefore, can be used as scaffold/membrane for tissue engineering. In the current study, we reviewed the latest trends in the application of bacterial cellulose (BC) polymers as a scaffold in different types of tissue, including bone, vascular, skin, and cartilage. Also, we mentioned the biological and mechanical advantages and disadvantages of BC polymers. Given the data presented in this study, BC polymer could be suggested as a favorable natural polymer in the design of tissue scaffolds. Implementing novel composites that combine this polymer with other materials through modern or rapid prototyping methods can open up a great prospect in the future of tissue engineering and regenerative medicine.
选择具有最佳再生潜力和最接近细胞外基质特性的材料是组织工程和再生医学的主要挑战之一。天然聚合物，如胶原蛋白、弹性蛋白和纤维素，在组织工程中被广泛用于此目的。细菌衍生的纤维素具有优异的机械性能、高亲水性、结晶度和高聚合度，因此可用作组织工程的支架/膜。在目前的研究中，我们综述了细菌纤维素 (BC) 聚合物作为不同类型组织（包括骨骼、血管、皮肤和软骨）支架的最新应用趋势。此外，我们还提到了 BC 聚合物的生物学和机械优缺点。鉴于本研究中提出的数据，BC 聚合物可被建议作为组织支架设计中一种有利的天然聚合物。通过现代或快速原型制造方法将这种聚合物与其他材料结合的新型复合材料，在组织工程和再生医学的未来将有很大的发展前景。
