Aghazadeh Mohammad Reza, Delfanian Sheyda, Aghakhani Pouria, Homaeigohar Shahin, Alipour Atefeh, Shahsavarani Hosein
Faculty of Chemical Engineering, Babol Noshirvani University of Technology, Babol 47148, Iran.
Department of Cell and Molecular Sciences, Faculty of Life Science and Biotechnology, Shahid Beheshti University, Tehran 1983963113, Iran.
Polymers (Basel). 2022 Apr 9;14(8):1531. doi: 10.3390/polym14081531.
In recent years, tissue engineering researchers have exploited a variety of biomaterials that can potentially mimic the extracellular matrix (ECM) for tissue regeneration. Natural cellulose, mainly obtained from bacterial (BC) and plant-based (PC) sources, can serve as a high-potential scaffold material for different regenerative purposes. Natural cellulose has drawn the attention of researchers due to its advantages over synthetic cellulose including its availability, cost effectiveness, perfusability, biocompatibility, negligible toxicity, mild immune response, and imitation of native tissues. In this article, we review recent in vivo and in vitro studies which aimed to assess the potential of natural cellulose for the purpose of soft (skin, heart, vein, nerve, etc.) and hard (bone and tooth) tissue engineering. Based on the current research progress report, it is sensible to conclude that this emerging field of study is yet to satisfy the clinical translation criteria, though reaching that level of application does not seem far-fetched.
近年来，组织工程研究人员开发了多种生物材料，这些材料有可能模拟细胞外基质（ECM）用于组织再生。天然纤维素主要来源于细菌（BC）和植物（PC），可作为用于不同再生目的的高潜力支架材料。天然纤维素因其相对于合成纤维素的优势而受到研究人员的关注，这些优势包括其可得性、成本效益、可灌注性、生物相容性、可忽略的毒性、轻微的免疫反应以及对天然组织的模仿。在本文中，我们综述了近期的体内和体外研究，这些研究旨在评估天然纤维素用于软（皮肤、心脏、静脉、神经等）组织和硬（骨骼和牙齿）组织工程的潜力。基于当前的研究进展报告，可以合理地得出结论，尽管达到该应用水平似乎并非遥不可及，但这个新兴的研究领域尚未满足临床转化标准。
