基于计算机断层扫描的骨骼肌和脂肪组织衰减：年龄、性别和肌肉的变化。
Computed tomography-based skeletal muscle and adipose tissue attenuation: Variations by age, sex, and muscle.
机构信息
Laboratory of Epidemiology and Population Science, Intramural Research Program, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA; Research Center in Sports Sciences, Health Sciences and Human Development - CIDESD, University Institute of Maia - ISMAI, Maia, Portugal; Portugal Football School, Portuguese Football Federation, Oeiras, Portugal.
Laboratory of Epidemiology and Population Science, Intramural Research Program, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA; Research Center in Sports Sciences, Health Sciences and Human Development - CIDESD, University Institute of Maia - ISMAI, Maia, Portugal.
出版信息
Exp Gerontol. 2021 Jul 1;149:111306. doi: 10.1016/j.exger.2021.111306. Epub 2021 Mar 10.
OBJECTIVE
This study aimed to investigate how skeletal muscle attenuation and adipose tissue (AT) attenuation of the quadriceps, hamstrings, paraspinal muscle groups and the psoas muscle vary according to the targeted muscles, sex, and age.
DESIGN
Population-based cross-sectional study.
SETTING
Community-dwelling old population in Reykjavik, Iceland.
SUBJECTS
A total of 5331 older adults (42.8% women), aged 66-96 years from the Age, Gene/Environment Susceptibility (AGES)- Reykjavik Study, who participated in the baseline visit (between 2002 and 2006) and had valid thigh and abdominal computed tomography (CT) scans were studied.
METHODS
Muscle attenuation and AT attenuation of the quadriceps, hamstrings, paraspinal muscle groups and the psoas muscle were determined using CT. Linear mixed model analysis of variance was performed for each sex, with skeletal muscle or AT attenuation as the dependent variable.
RESULTS
Muscle attenuation decreased, and AT attenuation increased with age in both sexes, and these differences were specific for each muscle, although not in all age groups. Age-related differences in muscle and AT attenuation varied with specific muscle. In general, for both sexes, skeletal muscle attenuation of the hamstrings declined more than average with age. Men and women displayed a different pattern in the age differences in AT attenuation for each muscle.
CONCLUSIONS
Our data support the hypotheses that skeletal muscle attenuation decreases, and AT attenuation increases with aging. In addition, our data add new evidence, supporting that age-related differences in skeletal muscle and AT attenuation vary between muscles.
目的
本研究旨在探讨根据目标肌肉、性别和年龄，股四头肌、腘绳肌、腰背肌群和腰大肌的骨骼肌衰减和脂肪组织（AT）衰减如何变化。
设计
基于人群的横断面研究。
地点
冰岛雷克雅未克的社区居住的老年人群。
受试者
共有 5331 名年龄在 66-96 岁的老年人（42.8%为女性），来自年龄、基因/环境易感性（AGES）-雷克雅未克研究，他们参加了基线访视（2002 年至 2006 年之间），并进行了有效的大腿和腹部计算机断层扫描（CT）检查。
方法
使用 CT 确定股四头肌、腘绳肌、腰背肌群和腰大肌的肌肉衰减和 AT 衰减。对于每个性别，使用线性混合模型方差分析，将骨骼肌或 AT 衰减作为因变量。
结果
在两性中，肌肉衰减随着年龄的增长而降低，AT 衰减随着年龄的增长而增加，这些差异是特定于每个肌肉的，尽管不是在所有年龄组中。肌肉和 AT 衰减的年龄相关差异因特定肌肉而异。一般来说，对于两性，随着年龄的增长，腘绳肌的骨骼肌衰减速度超过平均水平。男性和女性在各肌肉的 AT 衰减的年龄差异方面表现出不同的模式。
结论
我们的数据支持以下假设，即骨骼肌衰减减少，AT 衰减随年龄增长而增加。此外，我们的数据提供了新的证据，支持骨骼肌和 AT 衰减的年龄相关差异在肌肉之间存在差异。
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