Tang Liting, Jiang Baohong, Zhu Hongbo, Gao Ting, Zhou Yu, Gong Fuqiang, He Rongfang, Xie Liming, Li Yuehua
Department of Medical Oncology, The First Affiliated Hospital, University of South China, Hengyang, China.
Department of Pharmacy, The First Affiliated Hospital, University of South China, Hengyang, China.
Front Oncol. 2021 Feb 25;11:605988. doi: 10.3389/fonc.2021.605988. eCollection 2021.
Recent statistics show that breast cancer is among the most frequent cancers in clinical practice. It is also the second-leading cause of cancer-related deaths among women worldwide. CircRNAs are a new class of endogenous regulatory RNA molecules whose 5' end and 3' end are connected together to form a covalently closed single-stranded loop by back-splicing. CircRNAs present the advantages of disease-specific expression and excellent expression stability, and they can modulate gene expression at posttranscriptional and transcriptional levels. CircRNAs are abnormally expressed in multiple cancers, such as breast cancer, and drive the initiation and progression of cancer. In this review, we describe current knowledge about the functions of circRNAs and generalize their roles in various aspects of breast cancer, including cell proliferation, cell cycle, apoptosis, invasion and metastasis, autophagy, angiogenesis, drug resistance, and tumor immunity, and their prognostic and diagnostic value. This may add to a better understanding of the functions and roles of circRNAs in breast cancer, which may become new diagnostic and predictive biomarkers of breast cancer.
近期统计数据显示，乳腺癌是临床实践中最常见的癌症之一。它也是全球女性癌症相关死亡的第二大原因。环状RNA（circRNAs）是一类新型的内源性调控RNA分子，其5'端和3'端通过反向剪接连接在一起，形成共价闭合的单链环。环状RNA具有疾病特异性表达和出色的表达稳定性等优势，并且能够在转录后和转录水平上调节基因表达。环状RNA在多种癌症（如乳腺癌）中异常表达，并推动癌症的发生和发展。在本综述中，我们阐述了目前关于环状RNA功能的知识，并概括了它们在乳腺癌各个方面的作用，包括细胞增殖、细胞周期、凋亡、侵袭和转移、自噬、血管生成、耐药性以及肿瘤免疫，以及它们的预后和诊断价值。这可能有助于更好地理解环状RNA在乳腺癌中的功能和作用，环状RNA可能成为乳腺癌新的诊断和预测生物标志物。
