Zahra Qurat Ul Ain, Khan Qaiser Ali, Luo Zhaofeng
Core Facility Center for Life Sciences, Department of Biochemistry and Molecular Biology, School of Life Sciences, University of Sciences and Technology of China, Hefei, China.
Hefei National Lab for Physical Sciences at the Microscale and the Centers for Biomedical Engineering, University of Science and Technology of China, Hefei, China.
Front Oncol. 2021 Feb 25;11:632165. doi: 10.3389/fonc.2021.632165. eCollection 2021.
Cancer is a life-threatening concern worldwide. Sensitive and early-stage diagnostics of different cancer types can make it possible for patients to get through the best available treatment options to combat this menace. Among several new detection methods, aptamer-based biosensors (aptasensors) have recently shown promising results in terms of sensitivity, identification, or detection of either cancerous cells or the associated biomarkers. In this mini-review, we have summarized the most recent (2016-2020) developments in different approaches belonging to optical aptasensor technologies being widely employed for their simple operation, sensitivity, and early cancer diagnostics. Finally, we shed some light on limitations, advantages, and current challenges of aptasensors in clinical diagnostics, and we elaborated on some future perspectives.
癌症是全球范围内危及生命的重大问题。对不同类型癌症进行灵敏且早期的诊断，能使患者获得最佳可用治疗方案来对抗这一威胁。在多种新的检测方法中，基于适配体的生物传感器（适配体传感器）近来在癌细胞或相关生物标志物的灵敏度、识别或检测方面展现出了令人期待的成果。在这篇小型综述中，我们总结了光学适配体传感器技术不同方法的最新（2016 - 2020年）进展，这些技术因其操作简单、灵敏度高以及能用于癌症早期诊断而被广泛应用。最后，我们阐明了适配体传感器在临床诊断中的局限性、优势和当前面临的挑战，并阐述了一些未来展望。
