Department of Pharmaceutical Engineering, College of Life Sciences, Inner Mongolia Agricultural University, Hohhot, China.
Adv Exp Med Biol. 2021;1316:133-147. doi: 10.1007/978-981-33-6785-2_9.
Breakthroughs have been made in the cancer immunotherapy field focusing on utilizing T cells' antitumor immunity, and the lipid metabolism of tumor-associated B cells is not well studied compared to T cells. Accumulating evidence suggested that B cells also play important roles in tumor biology and antitumor immunity, especially the germinal center B cells that present in the tumor-related tertiary lymphoid structures. Due to scarce studies on lipid metabolisms of tumor-associated B cells, this chapter mainly summarized findings on B cell lipid metabolism and discussed B cell development and major transcription factors, tumor-associated B cell populations and their potential functions in antitumor immunity, fatty acid oxidation in germinal center B cells, and tumor microenvironment factors that potentially affect B cell lipid metabolism, focusing on hypoxia and nutrients competition, as well as lipid metabolites that affect B cell function, including cholesterol, geranylgeranyl pyrophosphate, oxysterols, and short-chain fatty acids.
在利用 T 细胞抗肿瘤免疫的癌症免疫治疗领域取得了突破，与 T 细胞相比，肿瘤相关 B 细胞的脂质代谢尚未得到充分研究。越来越多的证据表明，B 细胞在肿瘤生物学和抗肿瘤免疫中也发挥着重要作用，特别是存在于肿瘤相关三级淋巴结构中的生发中心 B 细胞。由于对肿瘤相关 B 细胞的脂质代谢研究甚少，本章主要总结了 B 细胞脂质代谢的研究结果，并讨论了 B 细胞的发育和主要转录因子、肿瘤相关 B 细胞群体及其在抗肿瘤免疫中的潜在功能、生发中心 B 细胞中的脂肪酸氧化，以及可能影响 B 细胞脂质代谢的肿瘤微环境因素，重点关注缺氧和营养竞争，以及影响 B 细胞功能的脂质代谢物，包括胆固醇、香叶基香叶基焦磷酸、氧化固醇和短链脂肪酸。
