Department of Epidemiology, University of Hawaii Cancer Center, Honolulu, HI, USA.
Department of Computational Medicine and Bioinformatics, North Campus Research Complex, University of Michigan, Ann Arbor, MI, USA.
FASEB J. 2021 Apr;35(4):e21524. doi: 10.1096/fj.202002184RR.
Maternal pre-pregnancy obesity may have an impact on both maternal and fetal health. We examined the microbiome recovered from placentas in a multi-ethnic maternal pre-pregnant obesity cohort, through an optimized microbiome protocol to enrich low bacterial biomass samples. We found that the microbiomes recovered from the placentas of obese pre-pregnant mothers are less abundant and less diverse when compared to those from mothers of normal pre-pregnancy weight. Microbiome richness also decreases from the maternal side to the fetal side, demonstrating heterogeneity by geolocation within the placenta. In summary, our study shows that the microbiomes recovered from the placentas are associated with pre-pregnancy obesity. IMPORTANCE: Maternal pre-pregnancy obesity may have an impact on both maternal and fetal health. The placenta is an important organ at the interface of the mother and fetus, and supplies nutrients to the fetus. We report that the microbiomes enriched from the placentas of obese pre-pregnant mothers are less abundant and less diverse when compared to those from mothers of normal pre-pregnancy weight. More over, the microbiomes also vary by geolocation within the placenta.
母体孕前肥胖可能会对母婴健康都产生影响。我们通过优化的微生物组方案来富集低细菌生物量样本，从多民族母体孕前肥胖队列中提取的胎盘微生物组进行了研究。与孕前体重正常的母亲相比，我们发现肥胖的孕前母亲的胎盘微生物组的丰度和多样性较低。从母体侧到胎儿侧，微生物组丰富度也降低，表明胎盘内的地理位置存在异质性。总之，我们的研究表明，从胎盘中提取的微生物组与孕前肥胖有关。重要的是，母体孕前肥胖可能会对母婴健康都产生影响。胎盘是母亲和胎儿之间的重要器官，为胎儿提供营养。我们报告说，与孕前体重正常的母亲相比，肥胖的孕前母亲的胎盘微生物组的丰度和多样性较低。此外，微生物组在胎盘内的地理位置上也存在差异。
