自控运动对乳腺癌康复患者红细胞抗氧化活性及肢体功能恢复的影响

Effect of Self-Controlled Exercise on Antioxidant Activity of Red Blood Cells and Functional Recovery of Limbs in Patients with Breast Cancer after Rehabilitation.

作者信息

Li Feifei, Liu Wei, Huo Fei, He Weifang, Yang Fan, Wei Jiabin, Wang Jing

机构信息

Two Areas of Galactophore Department, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, P.R. China.

One Areas of Galactophore Department, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, P.R. China.

出版信息

Iran J Public Health. 2021 Feb;50(2):306-314. doi: 10.18502/ijph.v50i2.5345.

DOI:10.18502/ijph.v50i2.5345

PMID:33747994

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7956092/

Abstract

BACKGROUND

We aimed to investigate the effect of self-controlled exercise on the antioxidant activity of red blood cells and the recovery of limb function in patients with breast cancer after rehabilitation.

METHODS

Overall 130 breast cancer patients admitted to the First Affiliated Hospital of Zhengzhou University, China from Feb 2018 to Jan 2019 were divided into intervention group and control group. The control group received perioperative care and chemotherapy, the intervention group implemented a self-controlled exercise program. Indexes were compared between the two groups before intervention, 3 months and 6 months after intervention.

RESULTS

The activity of erythrocyte superoxide dismutase (SOD) in the intervention group was significantly increased in the first 3 months (=0.030), and decreased from 3rd to 6th month (0.033). The glutathione peroxidase (GSH-Px) activity in the intervention group increased through the whole intervention period. The plasma malondialdehyde (MDA) in the intervention group was significantly decreased (=0.029, 0.012). After intervention for 3 months and 6 months, the 6MND distances in the intervention group were significantly longer (=0.001, 0.045). The average exercise time in the intervention group were significantly increased (=0.004, 0.000).

CONCLUSION

Self-controlled exercise can effectively improve the antioxidant ability of red blood cells in patients with breast cancer, improve the mobility of shoulder joints of the affected side and increase their exercise capacity, with good sustainability. It has positive effect on postoperative rehabilitation, could be used in long-term regular clinical work.

摘要

背景

我们旨在研究自我控制运动对乳腺癌患者康复后红细胞抗氧化活性及肢体功能恢复的影响。

方法

选取2018年2月至2019年1月在中国郑州大学第一附属医院收治的130例乳腺癌患者，分为干预组和对照组。对照组接受围手术期护理和化疗，干预组实施自我控制运动方案。比较两组干预前、干预后3个月和6个月的各项指标。

结果

干预组红细胞超氧化物歧化酶（SOD）活性在最初3个月显著升高（=0.030），从第3个月到第6个月下降（=0.033）。干预组谷胱甘肽过氧化物酶（GSH-Px）活性在整个干预期均升高。干预组血浆丙二醛（MDA）显著降低（=0.029，0.012）。干预3个月和6个月后，干预组6分钟步行距离显著延长（=0.001，0.045）。干预组平均运动时间显著增加（=0.004，0.000）。