Center for Outcomes Research and Economic Evaluation for Health (C2H), National Institute of Public Health, Wako, Saitama, Japan.
Department of Medicine, International University of Health and Welfare, Narita, Chiba, Japan.
Med Decis Making. 2021 Jul;41(5):597-606. doi: 10.1177/0272989X211001859. Epub 2021 Mar 23.
EQ-5D-Y is a preference-based measure for children and adolescents (aged 8-15 y). This is the first study to develop an EQ-5D-Y value set for converting EQ-5D-Y responses to index values.
We recruited 1047 respondents (aged 20-79 y) from the general population, stratified by gender and age group, in 5 Japanese cities. All data were collected through face-to-face surveys. Respondents were asked to value EQ-5D-Y states for a hypothetical 10-y-old child from a proxy perspective using composite time tradeoff (cTTO) and a discrete choice experiment (DCE). The discrete choice data were analyzed using a mixed logit model. Latent DCE values were then converted to a 0 (death)/1 (full health) scale by mapping them to the cTTO values.
The mean observed cTTO value of the worst health state [33333] was 0.20. Analysis of the DCE data showed that the coefficients of the domains related to mental functions ("Having pain or discomfort" and "Feeling worried, sad, or unhappy") were larger than those for the domains related to physical and social functions. By converting latent DCE values to a utility scale, we constructed a value set for EQ-5D-Y. No inconsistencies were observed. The minimum predicted score was 0.288 [33333], and the second-best score was 0.957 [12111].
A value set for EQ-5D-Y was successfully constructed. This is the first survey of an EQ-5D-Y value set. Interpreting the differences between EQ-5D-Y and EQ-5D-5L value sets is a future task with implications for health care policy.
EQ-5D-Y 是一种针对儿童和青少年（8-15 岁）的偏好测量工具。这是第一项旨在开发 EQ-5D-Y 量表的研究，旨在将 EQ-5D-Y 的反应转化为指数值。
我们在日本的 5 个城市中，按性别和年龄组分层，招募了 1047 名 20-79 岁的一般人群受访者。所有数据均通过面对面调查收集。受访者被要求从代理的角度使用综合时间权衡（cTTO）和离散选择实验（DCE）对假设的 10 岁儿童的 EQ-5D-Y 状态进行估值。离散选择数据使用混合对数模型进行分析。然后通过将潜在 DCE 值映射到 cTTO 值，将其转换为 0（死亡）/1（完全健康）的量表。
最差健康状态[33333]的平均观察到的 cTTO 值为 0.20。DCE 数据分析表明，与身体和社会功能相关的领域（“有疼痛或不适”和“感到担忧、悲伤或不快乐”）的域相关的系数大于与心理功能相关的域。通过将潜在的 DCE 值转换为效用量表，我们构建了 EQ-5D-Y 的价值体系。未观察到不一致。最低预测分数为 0.288[33333]，第二高分数为 0.957[12111]。
成功构建了 EQ-5D-Y 的价值体系。这是对 EQ-5D-Y 价值体系的首次调查。解释 EQ-5D-Y 和 EQ-5D-5L 价值体系之间的差异是未来的任务，对医疗保健政策具有重要意义。
