Transfer learning from ECG to PPG for improved sleep staging from wrist-worn wearables.

To develop a sleep staging method from wrist-worn accelerometry and the photoplethysmogram (PPG) by leveraging transfer learning from a large electrocardiogram (ECG) database.In previous work, we developed a deep convolutional neural network for sleep staging from ECG using the cross-spectrogram of ECG-derived respiration and instantaneous beat intervals, heart rate variability metrics, spectral characteristics, and signal quality measures derived from 5793 subjects in Sleep Heart Health Study (SHHS). We updated the weights of this model by transfer learning using PPG data derived from the Empatica E4 wristwatch worn by 105 subjects in the 'Emory Twin Study Follow-up' (ETSF) database, for whom overnight polysomnographic (PSG) scoring was available. The relative performance of PPG, and actigraphy (Act), plus combinations of these two signals, with and without transfer learning was assessed.The performance of our model with transfer learning showed higher accuracy (1-9 percentage points) and Cohen's Kappa (0.01-0.13) than those without transfer learning for every classification category. Statistically significant, though relatively small, incremental differences in accuracy occurred for every classification category as tested with the McNemar test. The out-of-sample classification performance using features from PPG and actigraphy for four-class classification was Accuracy (Acc) = 68.62% and Kappa = 0.44. For two-class classification, the performance was Acc = 81.49% and Kappa = 0.58.We proposed a combined PPG and actigraphy-based sleep stage classification approach using transfer learning from a large ECG sleep database. Results demonstrate that the transfer learning approach improves estimates of sleep state. The use of automated beat detectors and quality metrics means human over-reading is not required, and the approach can be scaled for large cross-sectional or longitudinal studies using wrist-worn devices for sleep staging.