Choi Jong-Whan, Hua Tuyen N M
Department of Biochemistry, Yonsei University Wonju College of Medicine, Wonju, Korea.
Department of Global Medical Science, Yonsei University Wonju College of Medicine, Wonju, Korea.
J Lifestyle Med. 2021 Jan 31;11(1):1-7. doi: 10.15280/jlm.2021.11.1.1.
Cancer incidences are rising globally. Therefore, in order to prevent and treat cancer, understanding cancer pathology is crucial. Tumors reprogram their metabolic phenotype to meet their needs for bioenergy, biosynthesis, and redox control. Alteration of the metabolic pathway has been proposed as the hallmark of cancer and explains the distinction between normal and cancer cells concerning nutrient utilization. Changes in the metabolism of nutrients such as glucose, amino acid, and fatty acid are associated with cancer risk. Luckily, this can be controlled with lifestyle modifications. Improvements in lifestyle behaviors to reduce cancer risks include a healthy diet, calorie restriction, and regular physical activity. This review begins with the understandings of metabolic reprogramming in cancer. Then, there will be evidence on the correlation between lifestyle factors and altered nutrient metabolism suggesting an application of lifestyle intervention for cancer risk reduction.
全球癌症发病率正在上升。因此，为了预防和治疗癌症，了解癌症病理学至关重要。肿瘤会重新编程其代谢表型，以满足其对生物能量、生物合成和氧化还原控制的需求。代谢途径的改变已被认为是癌症的标志，并解释了正常细胞和癌细胞在营养利用方面的区别。葡萄糖、氨基酸和脂肪酸等营养物质代谢的变化与癌症风险相关。幸运的是，这可以通过生活方式的改变来控制。改善生活方式行为以降低癌症风险包括健康饮食、热量限制和定期体育锻炼。本综述首先介绍对癌症中代谢重编程的理解。然后，将有证据表明生活方式因素与营养代谢改变之间的相关性，提示生活方式干预在降低癌症风险中的应用。
