Department of Psychology.
Department of Psychology and Neuroscience.
Psychol Addict Behav. 2021 Sep;35(6):749-759. doi: 10.1037/adb0000706. Epub 2021 Mar 25.
Conflicting evidence exists regarding the effects of cannabis on alcohol consumption, with some studies suggesting that cannabis is a substitute for alcohol, whereas others suggest that cannabis complements alcohol, thereby increasing drinking. Cannabidiol (CBD) has shown preclinical promise in decreasing alcohol consumption. This study explores the effects of cannabis containing different potencies of CBD and delta-9-tetrahydrocannabinol (THC) on alcohol consumption.
In this naturalistic observational study, 120 cannabis and alcohol-using adults (mean age = 33.2 years, 39.2% female, 83.3% white) were assigned to use one of three legal-market cannabis strains (predominantly THC, predominantly CBD, and CBD + THC) ad libitum for 5 days. Timeline Followback data on drinking and cannabis use were collected at a baseline session pertaining to the 30 days prior to the ad libitum period, and data regarding alcohol and cannabis use during the 5-day period were collected at follow-up (FU), immediately following the 5-day period.
Regression models tested strain differences in drinking outcomes during the ad libitum period. Orthogonal contrast codes were created comparing the CBD group with the other two groups and comparing the THC group with the CBD + THC group. The CBD group drank fewer drinks per drinking day ( < .05), had fewer alcohol use days ( < .05), and fewer alcohol and cannabis co-use days ( < .05) compared with the other groups. No differences emerged between the THC and the CBD + THC group.
Cannabinoid content should be considered in studies of alcohol and cannabis co-use. Findings are consistent with preclinical work, suggesting that CBD may be associated with decreased alcohol consumption. (PsycInfo Database Record (c) 2021 APA, all rights reserved).
关于大麻对酒精消费的影响存在相互矛盾的证据，一些研究表明大麻是酒精的替代品，而另一些研究则表明大麻补充了酒精，从而增加了饮酒量。大麻二酚（CBD）在减少酒精消费方面显示出了临床前的潜力。本研究探讨了含有不同 CBD 和 delta-9-四氢大麻酚（THC）效力的大麻对酒精消费的影响。
在这项自然观察研究中，120 名使用大麻和酒精的成年人（平均年龄=33.2 岁，39.2%为女性，83.3%为白人）被分配使用三种合法市场大麻菌株中的一种（主要含 THC、主要含 CBD 和 CBD+THC）自由摄取 5 天。在基线会话中收集了关于饮酒和大麻使用的时间线回溯数据，这些数据与自由摄取期前的 30 天有关，并且在 FU（紧随 5 天期之后）收集了关于 5 天期间的酒精和大麻使用的数据。
回归模型测试了自由摄取期内饮酒结果的菌株差异。创建了正交对比代码，比较了 CBD 组与其他两组，比较了 THC 组与 CBD+THC 组。与其他组相比，CBD 组每天饮酒量更少（<0.05），饮酒天数更少（<0.05），酒精和大麻共同使用天数更少（<0.05）。THC 组和 CBD+THC 组之间没有差异。
在酒精和大麻共同使用的研究中应考虑大麻素含量。这些发现与临床前工作一致，表明 CBD 可能与减少酒精消费有关。（PsycInfo 数据库记录（c）2021 APA，保留所有权利）。
