Department of Cardiovascular Medicine, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, People's Republic of China.
Key Laboratory of Molecular Cardiology of Shaanxi Province, Xi'an, Shaanxi, People's Republic of China.
BMC Cardiovasc Disord. 2021 Mar 31;21(1):159. doi: 10.1186/s12872-021-01966-y.
Electrocardiographic left ventricular hypertrophy (ECG-LVH) is a common manifestation of preclinical cardiovascular disease. The present study aimed to investigate risk factors for ECG-LVH and its prevalence in a cohort of young Chinese individuals.
(1) A total of 1515 participants aged 36-45 years old from our previously established cohort who were followed up in 2017 were included. Cross-sectional analysis was used to examine risk factors for ECG-LVH and its prevalence. (2) A total of 235 participants were recruited from the same cohort in 2013 and were followed up in 2017. Longitudinal analysis was used to determine the predictors of LVH occurrence over the 4-year period. We used multivariable logistic regression models to calculate OR and 95% CIs and to analyze risk factors for ECG-LVH.
In the cross-sectional analysis, the prevalence of LVH diagnosed by the Cornell voltage-duration product in the overall population and the hypertensive population was 4.6% and 8.8%, respectively. The logistic regression results shown that female sex [2.611 (1.591-4.583)], hypertension [2.638 (1.449-4.803)], systolic blood pressure (SBP) [1.021 (1.007-1.035)], serum uric acid (SUA) [1.004 (1.001-1.006)] and carotid intima-media thickness (CIMT) [67.670 (13.352-342.976)] were significantly associated with the risk of LVH (all P < 0.05). In the longitudinal analysis, fasting glucose [1.377 (1.087-1.754)], SBP [1.046 (1.013-1.080)] and female sex [1.242 (1.069-1.853)] were independent predictors for the occurrence of LVH in the fourth year of follow-up.
Our study suggested that female sex, hypertension, SBP, SUA and CIMT were significantly associated with the risk of LVH in young people. In addition, fasting glucose, SBP and female sex are independent predictors of the occurrence of LVH in a young Chinese general population.
心电图左心室肥厚（ECG-LVH）是临床前心血管疾病的常见表现。本研究旨在探讨年轻中国人 ECG-LVH 的危险因素及其患病率。
（1）共纳入来自我们之前建立的队列中 1515 名年龄在 36-45 岁的参与者，这些参与者于 2017 年进行了随访。采用横断面分析来检查 ECG-LVH 的危险因素及其患病率。（2）共纳入了 2013 年来自同一队列的 235 名参与者，他们于 2017 年进行了随访。采用纵向分析来确定 4 年内 LVH 发生的预测因素。我们使用多变量逻辑回归模型来计算 OR 和 95%置信区间，并分析 ECG-LVH 的危险因素。
在横断面分析中，整体人群和高血压人群中，由 Cornell 电压-时间乘积诊断的 LVH 患病率分别为 4.6%和 8.8%。逻辑回归结果显示，女性[2.611（1.591-4.583）]、高血压[2.638（1.449-4.803）]、收缩压（SBP）[1.021（1.007-1.035）]、血清尿酸（SUA）[1.004（1.001-1.006）]和颈动脉内膜-中层厚度（CIMT）[67.670（13.352-342.976）]与 LVH 风险显著相关（均 P<0.05）。在纵向分析中，空腹血糖[1.377（1.087-1.754）]、SBP[1.046（1.013-1.080）]和女性[1.242（1.069-1.853）]是随访第 4 年发生 LVH 的独立预测因素。
本研究表明，女性、高血压、SBP、SUA 和 CIMT 与年轻人的 LVH 风险显著相关。此外，空腹血糖、SBP 和女性是中国年轻人群中 LVH 发生的独立预测因素。
