Wang Ming, Zhao Lingyi, Wei Yao, Li Jianchu, Qi Zhenhong, Su Na, Zhao Chenyang, Zhang Rui, Tang Tianhong, Liu Sirui, Yang Fang, Zhu Lei, He Xujin, Li Changhui, Jiang Yuxin, Yang Meng
Department of Ultrasound, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Department of Biomedical Engineering, College of Engineering, Peking University, Beijing, China.
Biomed Opt Express. 2021 Feb 3;12(3):1236-1246. doi: 10.1364/BOE.411215. eCollection 2021 Mar 1.
This study aimed to identify features of breast intraductal lesions in photoacoustic/ultrasound (PA/US) imaging and compare PA/US with color Doppler flow/ultrasound (CDFI/US) in the evaluation of breast intraductal lesions. In the nine patients with 10 breast intraductal lesions and 8 patients with 8 benign lesions, total vessel scores evaluated from PA/US are significantly greater than those from CDFI/US (p=0.005). PA internal vessel scores and oxygen saturation (SO) score are significantly increased in breast intraductal lesions than in benign lesions (p=0.016, p=0.006). With a cutoff PA score (sum of PA internal vessel score and SO score) of 2.5, we obtained a sensitivity of 90% and a specificity of 87.5% in differentiation of two groups. PA/US upgraded 40% of breast intraductal lesions, and downgraded 50% of benign lesions from the Breast Imaging Reporting and Data System grading results based on CDFI/US. PA/US functional imaging has the potential in differentiating breast intraductal lesions.
本研究旨在识别光声/超声（PA/US）成像中乳腺导管内病变的特征，并在评估乳腺导管内病变时将PA/US与彩色多普勒血流/超声（CDFI/US）进行比较。在9例患有10个乳腺导管内病变的患者和8例患有8个良性病变的患者中，PA/US评估的总血管评分显著高于CDFI/US评估的总血管评分（p = 0.005）。与良性病变相比，乳腺导管内病变的PA内部血管评分和氧饱和度（SO）评分显著升高（p = 0.016，p = 0.006）。PA评分（PA内部血管评分与SO评分之和）截断值为2.5时，两组鉴别诊断的敏感性为90%，特异性为87.5%。基于CDFI/US的乳腺影像报告和数据系统分级结果显示，PA/US使40%的乳腺导管内病变分级上调，50%的良性病变分级下调。PA/US功能成像在鉴别乳腺导管内病变方面具有潜力。
