Cixi Institute of Biomedical Engineering, International Cooperation Base of Biomedical Materials Technology and Application, CAS Key Laboratory of Magnetic Materials and Devices, Zhejiang Engineering Research Center for Biomedical Materials, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo 315201, China.
School of Life Science, Institute of Engineering Medicine, Beijing Institute of Technology, Beijing 100081, China.
Nano Lett. 2021 Apr 14;21(7):2730-2737. doi: 10.1021/acs.nanolett.0c04455. Epub 2021 Apr 2.
Recently, magnetic particle imaging (MPI) has shown diverse biomedical applications such as cell tracking, lung perfusion, image-guided hyperthermia, and so forth. However, the currently reported MPI agents cannot achieve the possible theoretical detection limit of MPI (20 nM). A previous theoretical study has shown that the MPI performance of superparamagnetic iron oxide nanoparticles (SPIONs) can be enhanced by carbon supporting and metal doping. In the current study, a series of mixed metal metal-organic framework-derived carbon supporting SPIONs were synthesized by pyrolysis. Among the synthesized SPIONs, the MPI signal intensity of ZnFeO/C@PDA was found to be 4.7 times higher than the commercial MPI contrast (Vivotrax) having the same Fe concentration. ZnFeO/C@PDA also showed the highest MPI intensity in tumor-bearing-mice among all tested samples. Furthermore, they were found highly biocompatible and showed linear cell quantification. This work can open new avenues for the design and development of novel and high-performance MPI agents.
最近，磁性粒子成像（MPI）已经显示出了多种生物医学应用，如细胞跟踪、肺灌注、图像引导热疗等。然而，目前报道的 MPI 造影剂无法达到 MPI 的可能理论检测极限（20 nM）。先前的理论研究表明，通过碳支撑和金属掺杂可以提高超顺磁氧化铁纳米粒子（SPIONs）的 MPI 性能。在本研究中，通过热解合成了一系列混合金属金属有机框架衍生的碳支撑 SPIONs。在合成的 SPIONs 中，ZnFeO/C@PDA 的 MPI 信号强度比具有相同铁浓度的商业 MPI 对比剂（Vivotrax）高 4.7 倍。ZnFeO/C@PDA 在所有测试样本中在荷瘤小鼠中也表现出最高的 MPI 强度。此外，它们被发现具有高度的生物相容性，并表现出线性的细胞定量。这项工作为设计和开发新型高性能 MPI 造影剂开辟了新的途径。
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