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与COVID-19相关的口腔症状及其致病机制:文献综述

Oral Symptoms Associated with COVID-19 and Their Pathogenic Mechanisms: A Literature Review.

作者信息

Tsuchiya Hironori

机构信息

School of Dentistry, Asahi University, Mizuho, Gifu 501-0296, Japan.

出版信息

Dent J (Basel). 2021 Mar 11;9(3):32. doi: 10.3390/dj9030032.

Abstract

Since the worldwide spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, management of coronavirus disease 2019 (COVID-19) has been challenging for healthcare providers. The oral cavity is referred to as a target of SARS-CoV-2. The aim of this study was to review oral symptoms specific to COVID-19 patients from the point of view of symptom prevalence and pathogenesis and to speculate the pathogenic mechanisms underlying them. Scientific articles were retrieved by searching PubMed/MEDLINE, Google Scholar, medRxiv, and bioRxiv from 3 February 2020 to 31 December 2020, and they were reviewed by title, abstract, and text for relevance. The literature search indicated that COVID-19 patients frequently present with gustatory dysfunction, xerostomia, and oral mucosal lesions, while their prevalence is likely to vary by country, age, gender, and disease severity. Gustatory dysfunction and xerostomia appear at an early stage of SARS-CoV-2 infection and last relatively long. One of possible pathogenic mechanisms of both symptoms is attributed to the expression of viral cellular entry-relevant receptors in taste cells and salivary glands. Dental professionals who can first become aware of oral symptoms associated with COVID-19 will play a more active role in and make a greater contribution to diagnosis and prevention of COVID-19.

摘要

自严重急性呼吸综合征冠状病毒2(SARS-CoV-2)感染在全球蔓延以来,2019冠状病毒病(COVID-19)的管理对医疗服务提供者而言一直具有挑战性。口腔被认为是SARS-CoV-2的一个靶标。本研究的目的是从症状发生率和发病机制的角度回顾COVID-19患者特有的口腔症状,并推测其潜在的致病机制。通过检索2020年2月3日至2020年12月31日期间的PubMed/MEDLINE、谷歌学术、medRxiv和bioRxiv获取科学文章,并根据标题、摘要和正文对其相关性进行审查。文献检索表明,COVID-19患者经常出现味觉功能障碍、口干症和口腔黏膜病变,但其发生率可能因国家、年龄、性别和疾病严重程度而异。味觉功能障碍和口干症出现在SARS-CoV-2感染的早期,且持续时间相对较长。这两种症状可能的致病机制之一归因于味觉细胞和唾液腺中与病毒细胞进入相关受体的表达。能够首先意识到与COVID-19相关口腔症状的牙科专业人员将在COVID-19的诊断和预防中发挥更积极的作用并做出更大的贡献。

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