Department of Chemistry and Earth Sciences, College of Arts and Sciences, Qatar University, Doha 2713, Qatar.
Biosensors (Basel). 2021 Mar 21;11(3):89. doi: 10.3390/bios11030089.
The molecular imprinting polymers (MIPs) have shown their potential in various applications including pharmaceuticals, chemical sensing and biosensing, medical diagnosis, and environmental related issues, owing to their artificial selective biomimetic recognition ability. Despite the challenges posed in the imprinting and recognition of biomacromolecules, the use of MIP for the imprinting of large biomolecular oragnism such as viruses is of huge interest because of the necessity of early diagnosis of virus-induced diseases for clinical and point-of-care (POC) purposes. Thus, many fascinating works have been documented in which such synthetic systems undoubtedly explore a variety of potential implementations, from virus elimination, purification, and diagnosis to virus and bacteria-borne disease therapy. This study is focused comprehensively on the fabrication strategies and their usage in many virus-imprinted works that have appeared in the literature. The drawbacks, challenges, and perspectives are also highlighted.
分子印迹聚合物（MIPs）由于具有人工选择性仿生识别能力，在制药、化学传感和生物传感、医学诊断以及与环境相关的问题等各个领域的应用中显示出了它们的潜力。尽管在印迹和识别生物大分子方面存在挑战，但由于需要对病毒引起的疾病进行早期诊断以用于临床和即时护理（POC）目的，因此使用 MIP 对大型生物大分子或有机物如病毒进行印迹仍然具有很大的兴趣。因此，已经有很多引人入胜的工作记录在案，这些合成系统无疑探索了各种潜在的应用，从病毒消除、净化和诊断到病毒和细菌传播疾病的治疗。本研究全面关注了文献中出现的各种病毒印迹工作中使用的制备策略及其应用。还强调了缺点、挑战和展望。
