Department of Chemistry, State University of Londrina (UEL), Londrina 86051-990, Brazil.
Department of Microbiology, State University of Londrina (UEL), Londrina 86051-990, Brazil.
Biosensors (Basel). 2023 Mar 3;13(3):336. doi: 10.3390/bios13030336.
Rapid transmission and high mortality rates caused by the SARS-CoV-2 virus showed that the best way to fight against the pandemic was through rapid, accurate diagnosis in parallel with vaccination. In this context, several research groups around the world have endeavored to develop new diagnostic methods due to the disadvantages of the gold standard method, reverse transcriptase polymerase chain reaction (RT-PCR), in terms of cost and time consumption. Electrochemical and bioelectrochemical platforms have been important tools for overcoming the limitations of conventional diagnostic platforms, including accuracy, accessibility, portability, and response time. In this review, we report on several electrochemical sensors and biosensors developed for SARS-CoV-2 detection, presenting the concepts, fabrication, advantages, and disadvantages of the different approaches. The focus is devoted to highlighting the recent progress of electrochemical devices developed as next-generation field-deployable analytical tools as well as guiding future researchers in the manufacture of devices for disease diagnosis.
由 SARS-CoV-2 病毒引起的快速传播和高死亡率表明，抗击这一大流行病的最佳方法是通过快速、准确的诊断与疫苗接种并行。在这种情况下，由于金标准方法——逆转录聚合酶链反应（RT-PCR）——在成本和时间消耗方面存在劣势，世界各地的几个研究小组都在努力开发新的诊断方法。电化学和生物电化学平台已成为克服传统诊断平台在准确性、可及性、便携性和响应时间方面的局限性的重要工具。在这篇综述中，我们报告了几种用于 SARS-CoV-2 检测的电化学传感器和生物传感器，介绍了不同方法的概念、制造、优点和缺点。重点是突出作为下一代现场可部署分析工具开发的电化学器件的最新进展，并为疾病诊断器件的制造指导未来的研究人员。
