College of Animal Sciences, Zhejiang University, Hangzhou 310058, China.
Department of Radiation Oncology, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94115, USA.
Nutrients. 2020 Mar 30;12(4):959. doi: 10.3390/nu12040959.
The increasing incidence of obesity poses a great threat to public health worldwide. Recent reports also indicate the relevance of obesity in metabolic diseases. Chinese propolis (CP), as a well-studied natural nutraceutical, has shown a beneficial effect on alleviating diabetes mellitus. However, few studies have investigated the effect of CP on weight management and energy balance. We examined the beneficial effects of dietary CP on weight in high-fat diet-fed female and male mice and determined whether CP alters gut microbiota. In this study, dietary CP supplementation reduces body weight and improves insulin resistance in high-fat diet (HFD)-fed mice in a dose-dependent manner. CP treatment also reverses liver weight loss and triglyceride accumulation in association with hepatic steatosis. The 16S rRNA analysis of gut microbiota demonstrated that CP treatment modulates the composition in HFD-fed mice. Our study also suggests that male mice were more sensitive to CP treatment than female mice. Taken together, CP supplementation reduces weight gain and reverses gut microbiome dysbiosis induced by HFD. Further, the effects of CP treatment on metabolic biomarkers and microbiome structure differ by gender.
肥胖症的发病率不断上升，对全球公众健康构成了巨大威胁。最近的报告还表明肥胖与代谢性疾病有关。中国蜂胶（CP）作为一种研究充分的天然营养保健品，已被证明对缓解糖尿病具有有益作用。然而，很少有研究调查 CP 对体重管理和能量平衡的影响。我们研究了饮食 CP 对高脂肪饮食喂养的雌性和雄性小鼠体重的有益影响，并确定 CP 是否改变了肠道微生物群。在这项研究中，饮食 CP 补充以剂量依赖的方式降低了高脂肪饮食（HFD）喂养小鼠的体重并改善了胰岛素抵抗。CP 治疗还逆转了与肝脂肪变性相关的肝重减轻和甘油三酯积累。肠道微生物群的 16S rRNA 分析表明，CP 处理调节了 HFD 喂养小鼠的组成。我们的研究还表明，雄性小鼠对 CP 治疗比雌性小鼠更敏感。综上所述，CP 补充可减轻体重增加并逆转 HFD 引起的肠道微生物群失调。此外，CP 治疗对代谢生物标志物和微生物组结构的影响因性别而异。
