Centre for Emerging Zoonotic and Parasitic Diseases, National Institute for Communicable Diseases of the National Health Laboratory Services, Sandringham 2192, South Africa.
Centre for Viral Zoonoses, Department of Medical Virology, Faculty of Health Sciences, University of Pretoria, Pretoria 0001, South Africa.
Viruses. 2021 Mar 29;13(4):576. doi: 10.3390/v13040576.
Lagos bat virus (LBV), one of the 17 accepted viral species of the genus, was the first rabies-related virus described in 1956. This virus is endemic to the African continent and is rarely encountered. There are currently four lineages, although the observed genetic diversity exceeds existing lyssavirus species demarcation criteria. Several exposures to rabid bats infected with LBV have been reported; however, no known human cases have been reported to date. This review provides the history of LBV and summarizes previous knowledge as well as new detections. Genetic diversity, pathogenesis and prevention are re-evaluated and discussed.
拉各斯蝙蝠病毒(LBV)是 17 种已被认可的病毒属之一,于 1956 年首次被描述为与狂犬病相关的病毒。该病毒在非洲大陆流行,很少被发现。目前有四个谱系,但观察到的遗传多样性超过了现有的狂犬病病毒种划分标准。据报道,有几次接触感染了 LBV 的狂犬病蝙蝠的情况,但迄今为止,没有已知的人类病例报告。本文回顾了 LBV 的历史,总结了以往的知识以及新的发现。重新评估和讨论了遗传多样性、发病机制和预防。