Nienhuis Pieter H, van Praagh Gijs D, Glaudemans Andor W J M, Brouwer Elisabeth, Slart Riemer H J A
Department of Nuclear Medicine and Molecular Imaging, Medical Imaging Center, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands.
Department of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands.
J Pers Med. 2021 Mar 23;11(3):236. doi: 10.3390/jpm11030236.
Imaging is becoming increasingly important for the diagnosis of large vessel vasculitis (LVV). Atherosclerosis may be difficult to distinguish from LVV on imaging as both are inflammatory conditions of the arterial wall. Differentiating atherosclerosis from LVV is important to enable optimal diagnosis, risk assessment, and tailored treatment at a patient level. This paper reviews the current evidence of ultrasound (US), 2-deoxy-2-[18F]fluoro-D-glucose positron emission tomography (FDG-PET), computed tomography (CT), and magnetic resonance imaging (MRI) to distinguish LVV from atherosclerosis. In this review, we identified a total of eight studies comparing LVV patients to atherosclerosis patients using imaging-four US studies, two FDG-PET studies, and two CT studies. The included studies mostly applied different methodologies and outcome parameters to investigate vessel wall inflammation. This review reports the currently available evidence and provides recommendations on further methodological standardization methods and future directions for research.
成像对于大血管血管炎（LVV）的诊断正变得越来越重要。动脉粥样硬化在成像上可能难以与LVV区分，因为两者都是动脉壁的炎症性疾病。区分动脉粥样硬化与LVV对于在患者层面实现最佳诊断、风险评估和个性化治疗很重要。本文综述了超声（US）、2-脱氧-2-[18F]氟-D-葡萄糖正电子发射断层扫描（FDG-PET）、计算机断层扫描（CT）和磁共振成像（MRI）在区分LVV与动脉粥样硬化方面的现有证据。在本综述中，我们总共确定了八项使用成像技术比较LVV患者与动脉粥样硬化患者的研究——四项超声研究、两项FDG-PET研究和两项CT研究。纳入的研究大多采用不同的方法和结果参数来研究血管壁炎症。本综述报告了目前可用的证据，并就进一步的方法标准化方法和未来研究方向提供了建议。
