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评估染料物理化学性质对丝素蛋白基质中包埋及释放动力学的影响。

Assessing the Influence of Dyes Physico-Chemical Properties on Incorporation and Release Kinetics in Silk Fibroin Matrices.

作者信息

Tomoda Bruno Thorihara, Pacheco Murilo Santos, Abranches Yasmin Broso, Viganó Juliane, Perrechil Fabiana, De Moraes Mariana Agostini

机构信息

Department of Chemical Engineering, Institute of Environmental, Chemical and Pharmaceutical Sciences, Universidade Federal de São Paulo, Rua São Nicolau 210, Diadema 09913-030, Brazil.

出版信息

Polymers (Basel). 2021 Mar 5;13(5):798. doi: 10.3390/polym13050798.

DOI:10.3390/polym13050798
PMID:33807825
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7961930/
Abstract

Silk fibroin (SF) is a promising and versatile biodegradable protein for biomedical applications. This study aimed to develop a prolonged release device by incorporating SF microparticles containing dyes into SF hydrogels. The influence of dyes on incorporation and release kinetics in SF based devices were evaluated regarding their hydrophilicity, molar mass, and cationic/anionic character. Hydrophobic and cationic dyes presented high encapsulation efficiency, probably related to electrostatic and hydrophobic interactions with SF. The addition of SF microparticles in SF hydrogels was an effective method to prolong the release, increasing the release time by 10-fold.

摘要

丝素蛋白（SF）是一种用于生物医学应用的很有前景且用途广泛的可生物降解蛋白质。本研究旨在通过将含有染料的SF微粒掺入SF水凝胶中来开发一种长效释放装置。关于染料的亲水性、摩尔质量和阳离子/阴离子特性，评估了其对基于SF的装置中掺入和释放动力学的影响。疏水性和阳离子染料表现出高包封效率，这可能与它们与SF的静电和疏水相互作用有关。在SF水凝胶中添加SF微粒是延长释放的有效方法，释放时间增加了10倍。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e82c/7961930/cac768a6575a/polymers-13-00798-g008.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e82c/7961930/1d416ebdad3c/polymers-13-00798-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e82c/7961930/dc1b6974eae5/polymers-13-00798-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e82c/7961930/5006e3d4ef7e/polymers-13-00798-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e82c/7961930/459322b396c0/polymers-13-00798-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e82c/7961930/8db432dc3efa/polymers-13-00798-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e82c/7961930/cac768a6575a/polymers-13-00798-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e82c/7961930/87768b079705/polymers-13-00798-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e82c/7961930/6c29f8d93953/polymers-13-00798-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e82c/7961930/1d416ebdad3c/polymers-13-00798-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e82c/7961930/dc1b6974eae5/polymers-13-00798-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e82c/7961930/5006e3d4ef7e/polymers-13-00798-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e82c/7961930/459322b396c0/polymers-13-00798-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e82c/7961930/8db432dc3efa/polymers-13-00798-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e82c/7961930/cac768a6575a/polymers-13-00798-g008.jpg

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