Massachusetts College of Pharmacy and Health Sciences University, School of Pharmacy, Boston, MA 02115, USA.
Biosensors (Basel). 2021 Mar 30;11(4):99. doi: 10.3390/bios11040099.
Tremors are the most prevalent movement disorder that interferes with the patient's daily living, and physical activities, ultimately leading to a reduced quality of life. Due to the pathophysiology of tremor, developing effective pharmacotherapies, which are only suboptimal in the management of tremor, has many challenges. Thus, a range of therapies are necessary in managing this progressive, aging-associated disorder. Surgical interventions such as deep brain stimulation are able to provide durable tremor control. However, due to high costs, patient and practitioner preference, and perceived high risks, their utilization is minimized. Medical devices are placed in a unique position to bridge this gap between lifestyle interventions, pharmacotherapies, and surgical treatments to provide safe and effective tremor suppression. Herein, we review the mechanisms of action, safety and efficacy profiles, and clinical applications of different medical devices that are currently available or have been previously investigated for tremor suppression. These devices are primarily noninvasive, which can be a beneficial addition to the patient's existing pharmacotherapy and/or lifestyle intervention.
震颤是最常见的运动障碍，会干扰患者的日常生活和身体活动，最终导致生活质量下降。由于震颤的病理生理学原因，开发有效的药物治疗方法具有许多挑战，而这些方法仅对震颤的管理效果不佳。因此，需要一系列的治疗方法来管理这种进行性、与年龄相关的疾病。手术干预，如深部脑刺激，能够提供持久的震颤控制。然而，由于成本高、患者和医生的偏好以及感知到的高风险，其应用受到限制。医疗器械在生活方式干预、药物治疗和手术治疗之间架起了桥梁，能够提供安全有效的震颤抑制。在此，我们回顾了不同医疗器械的作用机制、安全性和疗效概况，以及它们在目前或以前用于震颤抑制的临床应用。这些设备主要是非侵入性的，可以作为患者现有药物治疗和/或生活方式干预的有益补充。
