Ortega Israel, Duleba Antoni J
IVI-Madrid, Madrid, Spain.
Department of Reproductive Medicine, University of California, San Diego, San Diego, California.
Ann N Y Acad Sci. 2015 Aug;1348(1):86-96. doi: 10.1111/nyas.12875.
Resveratrol, a natural polyphenol found in grapes, berries, and medicinal plants, exhibits antioxidant and anti-inflammatory activities and has been proposed to be a longevity-prolonging agent. There is also growing evidence that resveratrol has cardioprotective properties and beneficial effects on both glucose and lipid metabolism. Recently, several studies have examined the use of resveratrol as a therapeutic agent to treat numerous pathological and metabolic disorders. Herein, we present insights into the mechanisms of action, biological effects, and current evidence of actions of resveratrol on the ovary. In vitro, resveratrol inhibits proliferation and androgen production by theca-interstitial cells. Resveratrol also exerts a cytostatic, but not cytotoxic, effect on granulosa cells, while decreasing aromatization and vascular endothelial growth factor expression. In vivo, resveratrol treatment reduced the size of adipocytes and improved estrus cyclicity in the previously acyclic rat model of polycystic ovary syndrome (PCOS). In addition, resveratrol increased the ovarian follicular reserve and prolonged the ovarian life span in rats. Taken together, resveratrol emerges as a potential therapeutic agent to treat conditions associated with androgen excess, such as PCOS. The efficacy of resveratrol in the treatment of gynecological conditions requires further investigation.
白藜芦醇是一种存在于葡萄、浆果和药用植物中的天然多酚，具有抗氧化和抗炎活性，被认为是一种延年益寿的物质。越来越多的证据表明，白藜芦醇具有心脏保护作用以及对葡萄糖和脂质代谢的有益影响。最近，多项研究探讨了白藜芦醇作为治疗多种病理和代谢紊乱的治疗剂的用途。在此，我们对白藜芦醇对卵巢的作用机制、生物学效应及当前证据进行了深入分析。在体外，白藜芦醇可抑制卵泡膜间质细胞的增殖和雄激素生成。白藜芦醇对颗粒细胞也具有细胞生长抑制作用而非细胞毒性作用，同时可降低芳香化作用和血管内皮生长因子的表达。在体内，在先前无排卵的多囊卵巢综合征（PCOS）大鼠模型中，白藜芦醇治疗可减小脂肪细胞大小并改善发情周期。此外，白藜芦醇可增加大鼠的卵巢卵泡储备并延长卵巢寿命。综上所述，白藜芦醇有望成为治疗与雄激素过多相关疾病（如PCOS）的潜在治疗剂。白藜芦醇在治疗妇科疾病方面的疗效有待进一步研究。
