Departamento Ciencias Biomédicas, Biomedical Research Institute, Universidad Cardenal Herrera-CEU, CEU Universities, Av. Seminario s/n, 46113 Valencia, Spain.
Thematic Cooperative Health Network for Research in Ophthalmology (Oftared), Carlos III Health Institute, 28220 Madrid, Spain.
Biomolecules. 2021 Mar 30;11(4):514. doi: 10.3390/biom11040514.
The aim of this study was to identify a relation between the clinical characteristics and differences in lipid peroxidation in the subretinal fluid (SRF) of rhegmatogenous retinal detached patients by malondialdehyde (MDA) quantification. We collected 65 SRF samples from consecutive patients during scleral buckling surgery in rhegmatogenous retinal detachment (RRD) eyes. In addition to a complete ophthalmic evaluation, we studied the refractive status, evolution time, and the number of detached retinal quadrants to establish the extension of RRD. We studied the clinical aspects and oxidative stress and compared the characteristics among groups. We found that neither the evolution time of RRD nor the patients' age correlated with the MDA concentration in the SRF. The MDA and the protein content of the SRF increased in the patients with high myopia and with more extended RRD. Our results suggest that oxidative imbalance was important in more extended retinal detachment (RD) and in myopic eyes and should be taken into account in the managing of these cases.
本研究旨在通过丙二醛 (MDA) 定量分析，确定孔源性视网膜脱离患者视网膜下液 (SRF) 中临床特征与脂质过氧化差异之间的关系。我们在巩膜扣带手术中收集了 65 例连续孔源性视网膜脱离 (RRD) 患者的 SRF 样本。除了全面的眼科评估外，我们还研究了屈光状态、演变时间和脱离视网膜象限的数量，以确定 RRD 的扩展程度。我们研究了临床方面和氧化应激，并比较了各组的特征。我们发现，RRD 的演变时间和患者年龄均与 SRF 中的 MDA 浓度无关。在高度近视和 RRD 扩展更多的患者中，MDA 和 SRF 的蛋白含量增加。我们的结果表明，氧化失衡在更广泛的视网膜脱离 (RD) 和近视眼中很重要，在处理这些病例时应考虑到这一点。
