Balsa Carlos, Lopes Isabel, Guarda Teresa, Rufino José
Research Centre in Digitalization and Intelligent Robotics (CeDRI), Instituto Politécnico de Bragança, Campus de Santa Apolónia, 5300-253 Bragança, Portugal.
Applied Management Research Unit (UNIAG), Instituto Politécnico de Bragança, Campus de Santa Apolónia, 5300-253 Bragança, Portugal.
Comput Math Organ Theory. 2021 Mar 30:1-19. doi: 10.1007/s10588-021-09327-y.
A small number of individuals infected within a community can lead to the rapid spread of the disease throughout that community, leading to an epidemic outbreak. This is even more true for highly contagious diseases such as COVID-19, known to be caused by the new coronavirus SARS-CoV-2. Mathematical models of epidemics allow estimating several impacts on the population and, therefore, are of great use for the definition of public health policies. Some of these measures include the isolation of the infected (also known as quarantine), and the vaccination of the susceptible. In a possible scenario in which a vaccine is available, but with limited access, it is necessary to quantify the levels of vaccination to be applied, taking into account the continued application of preventive measures. This work concerns the simulation of the spread of the COVID-19 disease in a community by applying the Monte Carlo method to a Susceptible-Exposed-Infective-Recovered (SEIR) stochastic epidemic model. To handle the computational effort involved, a simple parallelization approach was adopted and deployed in a small HPC cluster. The developed computational method allows to realistically simulate the spread of COVID-19 in a medium-sized community and to study the effect of preventive measures such as quarantine and vaccination. The results show that an effective combination of vaccination with quarantine can prevent the appearance of major epidemic outbreaks, even if the critical vaccination coverage is not reached.
社区内少数感染者可导致疾病在整个社区迅速传播,引发疫情爆发。对于像由新型冠状病毒SARS-CoV-2引起的COVID-19这样的高传染性疾病来说更是如此。流行病数学模型有助于估计对人群的多种影响,因此,对制定公共卫生政策非常有用。其中一些措施包括隔离感染者(也称为检疫)以及对易感人群进行疫苗接种。在一种可能的情况下,有疫苗可用,但获取有限,有必要在考虑继续实施预防措施的情况下,量化要应用的疫苗接种水平。这项工作涉及通过将蒙特卡洛方法应用于易感-暴露-感染-康复(SEIR)随机流行病模型来模拟COVID-19疾病在社区中的传播。为处理所涉及的计算工作,采用了一种简单的并行化方法并部署在一个小型高性能计算集群中。所开发的计算方法能够逼真地模拟COVID-19在一个中等规模社区中的传播,并研究检疫和疫苗接种等预防措施的效果。结果表明,即使未达到关键疫苗接种覆盖率,疫苗接种与检疫的有效结合也可防止重大疫情爆发的出现。