Faam Bita, Ghadiri Ata A, Ghaffari Mohammad Ali, Totonchi Mehdi, Khorsandi Layasadat
Cellular & Molecular Research Center, Medical Basic Sciences Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Immunology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Int J Endocrinol Metab. 2021 Jan 26;19(1):e105669. doi: 10.5812/ijem.105669. eCollection 2021 Jan.
Oxidative stress is commonly accrued in thyroid tissue during hormone synthesis.
We aimed to examine oxidative stress in patients with thyroid cancer, benign thyroid nodules, and healthy individuals.
In this study, 138 individuals were involved. Among the selected participants, 108 had thyroid nodules, including 30 papillary thyroid cancer (PTC), 30 follicular thyroid cancer (FTC), six anaplastic thyroid cancer (ATC), 12 medullary thyroid cancer (MTC), and 30 benign nodules. In addition, 30 individuals were selected as a healthy control group. The levels of total antioxidant capacity (TAC) and total oxidant status (TOS) of thyroid tissue were measured using the ELISA method, and the oxidative stress index (OSI) was calculated.
The TAC level was significantly lower in MTC and FTC subtypes than in controls. The TOS level was considerably higher in the MTC group than in the control and benign nodule groups. The TOS level was not changed in other groups. The OSI was considerably higher in MTC and FTC subtypes. The TAC and OSI in benign nodules were significantly lower and higher than those of controls, respectively. The OSI was higher in female patients than in males.
The OSI can not be considered a diagnostic biomarker for benign nodules and MTC. The diverse oxidative stress status between genders may be related to the elevated cancer incidence in females.
在激素合成过程中，甲状腺组织中通常会累积氧化应激。
我们旨在研究甲状腺癌患者、甲状腺良性结节患者和健康个体的氧化应激情况。
本研究纳入了138名个体。在选定的参与者中，108人有甲状腺结节，包括30例乳头状甲状腺癌（PTC）、30例滤泡状甲状腺癌（FTC）、6例未分化甲状腺癌（ATC）、12例髓样甲状腺癌（MTC）和30例良性结节。此外，选取30名个体作为健康对照组。采用酶联免疫吸附测定法（ELISA）测量甲状腺组织的总抗氧化能力（TAC）和总氧化状态（TOS），并计算氧化应激指数（OSI）。
MTC和FTC亚型的TAC水平显著低于对照组。MTC组的TOS水平显著高于对照组和良性结节组。其他组的TOS水平没有变化。MTC和FTC亚型的OSI显著更高。良性结节的TAC和OSI分别显著低于和高于对照组。女性患者的OSI高于男性患者。
OSI不能被视为良性结节和MTC的诊断生物标志物。不同性别之间氧化应激状态的差异可能与女性癌症发病率升高有关。
