银氨氟化物和碘化钾对粪肠球菌、奈瑟菌和微小消化链球菌的抗菌效果。
Antibacterial effect of silver diamine fluoride and potassium iodide against E. faecalis, A. naeslundii and P. micra.
机构信息
Department of Restorative, Preventive and Pediatric Dentistry, School of Dental Medicine, University of Bern, Freiburgstrasse 7, 3010, Bern, Switzerland.
Department of Periodontology and Operative Dentistry, University Medical Center of the Johannes Gutenberg-University, Mainz, Germany.
出版信息
BMC Oral Health. 2021 Apr 7;21(1):175. doi: 10.1186/s12903-021-01531-1.
BACKGROUND
The aim of this study was to determine in vitro the bactericidal potential of 38% silver diamine fluoride (SDF) alone, potassium iodide (PI) alone, and the two in combination (SDF + PI) against three bacterial species commonly found in root canal samples (Enterococcus faecalis, Actinomyces naeslundii and Parvimonas micra).
METHODS
The potential bactericidal rates for SDF, PI and SDF + PI against E. faecalis, A. naeslundii and P. micra were calculated as reduction of bacteria colony forming units.
RESULTS
The bactericidal potential of SDF was at 99.97-100% against E. faecalis and 100% against A. naeslundii and P. micra. SDF + PI showed a 100% bactericidal effect against P. micra, 99.89-99.98% against E. faecalis and 99.98-100% against A. naeslundii. The bactericidal effect of PI was 99.51-99.98% against E. faecalis, 99.27-99.95% against A. naeslundii and 99.93-100% against P. micra. The differences between controls and bacteria exposed to the antibacterial agents were statistically significant (p < 0.05).
CONCLUSIONS
SDF had an effective bactericidal effect against the examined bacteria. However, the limitations of this in vitro study do not allow a recommendation of the employment of these solutions as root canal irrigants. Additional investigations are necessary to assess their endodontic clinical applicability.
背景
本研究旨在测定 38%的银胺氟（SDF）、碘化钾（PI）单独使用，以及二者联合使用（SDF+PI）对三种常见于根管样本中的细菌（粪肠球菌、内氏放线菌和小韦荣球菌）的体外杀菌潜力。
方法
通过计算细菌菌落形成单位的减少来计算 SDF、PI 和 SDF+PI 对粪肠球菌、内氏放线菌和小韦荣球菌的潜在杀菌率。
结果
SDF 对粪肠球菌的杀菌潜力为 99.97-100%，对内氏放线菌和小韦荣球菌的杀菌潜力为 100%。SDF+PI 对小韦荣球菌表现出 100%的杀菌效果，对粪肠球菌为 99.89-99.98%，对内氏放线菌为 99.98-100%。PI 对粪肠球菌的杀菌效果为 99.51-99.98%，对内氏放线菌为 99.27-99.95%，对小韦荣球菌为 99.93-100%。与对照组相比，暴露于抗菌剂的细菌差异具有统计学意义（p<0.05）。
结论
SDF 对所研究的细菌具有有效的杀菌作用。然而，这项体外研究的局限性不允许推荐这些溶液作为根管冲洗液。需要进一步的研究来评估它们在牙髓临床中的适用性。
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