Song Wonmoon, Ko Junghyeon, Choi Young Hwan, Hwang Nathaniel S
School of Chemical and Biological Engineering, Institute of Chemical Processes, Seoul National University, Seoul 08826, Republic of Korea.
APL Bioeng. 2021 Apr 1;5(2):021502. doi: 10.1063/5.0037793. eCollection 2021 Jun.
Enzymes play a central role in fundamental biological processes and have been traditionally used to trigger various processes. In recent years, enzymes have been used to tune biomaterial responses and modify the chemical structures at desired sites. These chemical modifications have allowed the fabrication of various hydrogels for tissue engineering and therapeutic applications. This review provides a comprehensive overview of recent advancements in the use of enzymes for hydrogel fabrication. Strategies to enhance the enzyme function and improve biocompatibility are described. In addition, we describe future opportunities and challenges for the production of enzyme-mediated crosslinkable hydrogels.
酶在基本生物学过程中发挥着核心作用，传统上一直被用于触发各种过程。近年来，酶已被用于调节生物材料的反应并在所需位点修饰化学结构。这些化学修饰使得能够制造用于组织工程和治疗应用的各种水凝胶。本文综述全面概述了酶在水凝胶制造应用中的最新进展。描述了增强酶功能和改善生物相容性的策略。此外，我们还阐述了生产酶介导的可交联水凝胶的未来机遇和挑战。
