Phiri Peter, Ramakrishnan Rema, Rathod Shanaya, Elliot Kathryn, Thayanandan Tony, Sandle Natasha, Haque Nyla, Chau Steven Wh, Wong Oscar Wh, Chan Sandra Sm, Wong Evelyn Ky, Raymont Vanessa, Au-Yeung Sheena K, Kingdon David, Delanerolle Gayathri
Southern Health NHS Foundation Trust, Research and Development Dept., Clinical Trials Facility, Moorgreen Hospital, Southampton SO30 3JB, UK.
Primary Care, Population Sciences and Medical Education, Faculty of Medicine, University of Southampton, Aldermoor Health Centre, Southampton SO16 5ST, UK.
EClinicalMedicine. 2021 Apr;34:100806. doi: 10.1016/j.eclinm.2021.100806. Epub 2021 Apr 6.
The global impact of COVID-19 pandemic continues to affect the lives of billions of people with recurrent waves. Healthcare systems are struggling to manage pre-existing patient care and recurring covid-19 demands. As a result, we evaluated the mental health impact using systematic review and meta-analysis.
A comprehensive search was undertaken from April 2020 to 22nd January 2021 using multiple electronic databases. A systematic review protocol was developed and published on PROSPERO registration; CRD42020181481. A random-effects model was used to compute pooled estimates of anxiety, depression, PTSD, insomnia and suicidal thoughts.
Our search yielded 11,295 studies and of those 287 met the inclusion criteria. The meta-analysis of 206 studies revealed minimal differences in prevalence of anxiety, depression, and PTSD among HCPs compared with the public during the pandemic but higher prevalence of suicidal thoughts/ideation or self-harm (11% vs 5.8%) and lower prevalence of wellbeing (28.2% vs 52.6%) among the public compared to HCPs.
The pandemic has led to a high mental health burden especially amongst HCPs and higher suicidal ideation and lower wellbeing in general public which warrants further investigation and management globally. These findings highlight an emerging critical public health issue that requires urgent solutions.
新冠疫情的全球影响持续冲击着数十亿人的生活，疫情反复爆发。医疗系统在努力应对既有的患者护理需求以及不断出现的新冠疫情相关需求方面面临困难。因此，我们通过系统评价和荟萃分析评估了其对心理健康的影响。
于2020年4月至2021年1月22日使用多个电子数据库进行了全面检索。制定了一项系统评价方案并在国际前瞻性系统评价注册库（PROSPERO）上发布；注册号为CRD42020181481。采用随机效应模型计算焦虑、抑郁、创伤后应激障碍、失眠和自杀念头的合并估计值。
我们的检索共得到11295项研究，其中287项符合纳入标准。对206项研究的荟萃分析显示，在疫情期间，医护人员中焦虑、抑郁和创伤后应激障碍的患病率与公众相比差异不大，但公众中自杀念头/想法或自我伤害的患病率更高（11%对5.8%），幸福感患病率更低（28.2%对52.6%）。
疫情导致了很高的心理健康负担，尤其是在医护人员中，并且公众中自杀念头增多，总体幸福感降低，这需要在全球范围内进行进一步调查和管理。这些发现凸显了一个新出现的关键公共卫生问题，需要紧急解决。
