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本文引用的文献

1
SARS-CoV-2, SARS-CoV, and MERS-CoV viral load dynamics, duration of viral shedding, and infectiousness: a systematic review and meta-analysis.SARS-CoV-2、SARS-CoV 和 MERS-CoV 的病毒载量动态、病毒脱落持续时间和传染性:系统评价和荟萃分析。
Lancet Microbe. 2021 Jan;2(1):e13-e22. doi: 10.1016/S2666-5247(20)30172-5. Epub 2020 Nov 19.
2
Repurposed Antiviral Drugs for Covid-19 - Interim WHO Solidarity Trial Results.用于治疗新冠肺炎的抗病毒药物 repurposed - 世界卫生组织团结试验中期结果
N Engl J Med. 2021 Feb 11;384(6):497-511. doi: 10.1056/NEJMoa2023184. Epub 2020 Dec 2.
3
A Proposed Framework and Timeline of the Spectrum of Disease Due to SARS-CoV-2 Infection: Illness Beyond Acute Infection and Public Health Implications.新型冠状病毒感染所致疾病谱的拟议框架及时间线:急性感染之外的病症及公共卫生影响
JAMA. 2020 Dec 8;324(22):2251-2252. doi: 10.1001/jama.2020.22717.
4
Cardiac Involvement of COVID-19: A Comprehensive Review.COVID-19 相关心脏问题:全面综述。
Am J Med Sci. 2021 Jan;361(1):14-22. doi: 10.1016/j.amjms.2020.10.002. Epub 2020 Oct 6.
5
Update: Characteristics of Symptomatic Women of Reproductive Age with Laboratory-Confirmed SARS-CoV-2 Infection by Pregnancy Status - United States, January 22-October 3, 2020.更新:2020 年 1 月 22 日至 10 月 3 日,美国按妊娠状况划分的有症状育龄期女性中经实验室确认感染 SARS-CoV-2 的特征。
MMWR Morb Mortal Wkly Rep. 2020 Nov 6;69(44):1641-1647. doi: 10.15585/mmwr.mm6944e3.
6
Chest CT findings of coronavirus disease 2019 (COVID-19): A comprehensive meta-analysis of 9907 confirmed patients.新型冠状病毒肺炎(COVID-19)的胸部 CT 表现:9907 例确诊患者的综合荟萃分析。
Clin Imaging. 2021 Feb;70:101-110. doi: 10.1016/j.clinimag.2020.10.035. Epub 2020 Oct 25.
7
Treating COVID-19: are we missing out the window of opportunity?治疗 COVID-19:我们是否错失了机会之窗?
J Antimicrob Chemother. 2021 Jan 19;76(2):283-285. doi: 10.1093/jac/dkaa442.
8
[COVID-19 and thromboprophylaxis: Recommendations for our clinical practice in Primary Care].[新型冠状病毒肺炎与血栓预防:基层医疗临床实践建议]
Semergen. 2020 Oct;46(7):479-486. doi: 10.1016/j.semerg.2020.07.007. Epub 2020 Sep 18.
9
Recommendations for antibacterial therapy in adults with COVID-19 - an evidence based guideline.成人 COVID-19 抗菌治疗建议——基于证据的指南。
Clin Microbiol Infect. 2021 Jan;27(1):61-66. doi: 10.1016/j.cmi.2020.09.041. Epub 2020 Oct 1.
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Thoracic imaging tests for the diagnosis of COVID-19.用于诊断新型冠状病毒肺炎的胸部影像学检查
Cochrane Database Syst Rev. 2020 Sep 30;9:CD013639. doi: 10.1002/14651858.CD013639.pub2.

[基层医疗管理中新冠病毒病的基本方面]

[Basic aspects of COVID-19 for management from primary care].

作者信息

Molero-García José María, Arranz-Izquierdo Javier, Gutiérrez-Pérez María Isabel, Redondo Sánchez Jesús María

机构信息

CS San Andrés, DA CENTRO (SERMAS), Grupo de trabajo de enfermedades infecciosas de SemFYC, Madrid, España.

Instituto de Investigación Sanitaria de Illes Balears (Idisba), CS Escola Graduada, Ibsalut, Palma de Mallorca, Illes Balears, Grupo de trabajo de enfermedades infecciosas de SemFYC, Illes Balears, España.

出版信息

Aten Primaria. 2021 Jun-Jul;53(6):101966. doi: 10.1016/j.aprim.2020.12.007. Epub 2020 Dec 26.

DOI:10.1016/j.aprim.2020.12.007
PMID:33852979
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7762708/
Abstract

SARS-CoV-2 is transmitted from person to person by inhalation or contact with respiratory droplets and aerosols. The median incubation period is 5.1 days. Fever, dry cough, dyspnea and fatigue are the most common symptoms. Almost half of the cases are asymptomatic. The spectrum of disease varies from mild (81%) to critical (5%). Older age, male gender and comorbidities negatively impact on the severity and mortality of COVID-19. The diagnosis of acute COVID-19 is made with RT-PCR or antigenic detection tests. In hospital patients, remdesivir reduces recovery time. Oral steroids are recommended for severe or critical cases requiring oxygen therapy or mechanical ventilation. Thromboprophylaxis is recommended in all severe and non-severe cases with high thrombotic risk. Antibiotherapy is limited to cases of high suspicion of bacterial superinfection. Mild-moderate and severe cases after discharge from hospital should be clinically monitored for a minimum period of two weeks.

摘要

严重急性呼吸综合征冠状病毒2(SARS-CoV-2)通过吸入或接触呼吸道飞沫和气溶胶在人与人之间传播。中位潜伏期为5.1天。发热、干咳、呼吸困难和乏力是最常见的症状。几乎一半的病例无症状。疾病谱从轻度(81%)到危重症(5%)不等。老年、男性和合并症对新型冠状病毒肺炎(COVID-19)的严重程度和死亡率有负面影响。急性COVID-19的诊断通过逆转录聚合酶链反应(RT-PCR)或抗原检测试验进行。对于住院患者,瑞德西韦可缩短恢复时间。对于需要吸氧治疗或机械通气的重症或危重症病例,建议使用口服类固醇。对于所有具有高血栓形成风险的重症和非重症病例,建议进行血栓预防。抗生素治疗仅限于高度怀疑细菌二重感染的病例。出院后的轻中度和重症病例应至少进行两周的临床监测。