Molero-García José María, Arranz-Izquierdo Javier, Gutiérrez-Pérez María Isabel, Redondo Sánchez Jesús María
CS San Andrés, DA CENTRO (SERMAS), Grupo de trabajo de enfermedades infecciosas de SemFYC, Madrid, España.
Instituto de Investigación Sanitaria de Illes Balears (Idisba), CS Escola Graduada, Ibsalut, Palma de Mallorca, Illes Balears, Grupo de trabajo de enfermedades infecciosas de SemFYC, Illes Balears, España.
Aten Primaria. 2021 Jun-Jul;53(6):101966. doi: 10.1016/j.aprim.2020.12.007. Epub 2020 Dec 26.
SARS-CoV-2 is transmitted from person to person by inhalation or contact with respiratory droplets and aerosols. The median incubation period is 5.1 days. Fever, dry cough, dyspnea and fatigue are the most common symptoms. Almost half of the cases are asymptomatic. The spectrum of disease varies from mild (81%) to critical (5%). Older age, male gender and comorbidities negatively impact on the severity and mortality of COVID-19. The diagnosis of acute COVID-19 is made with RT-PCR or antigenic detection tests. In hospital patients, remdesivir reduces recovery time. Oral steroids are recommended for severe or critical cases requiring oxygen therapy or mechanical ventilation. Thromboprophylaxis is recommended in all severe and non-severe cases with high thrombotic risk. Antibiotherapy is limited to cases of high suspicion of bacterial superinfection. Mild-moderate and severe cases after discharge from hospital should be clinically monitored for a minimum period of two weeks.
严重急性呼吸综合征冠状病毒2(SARS-CoV-2)通过吸入或接触呼吸道飞沫和气溶胶在人与人之间传播。中位潜伏期为5.1天。发热、干咳、呼吸困难和乏力是最常见的症状。几乎一半的病例无症状。疾病谱从轻度(81%)到危重症(5%)不等。老年、男性和合并症对新型冠状病毒肺炎(COVID-19)的严重程度和死亡率有负面影响。急性COVID-19的诊断通过逆转录聚合酶链反应(RT-PCR)或抗原检测试验进行。对于住院患者,瑞德西韦可缩短恢复时间。对于需要吸氧治疗或机械通气的重症或危重症病例,建议使用口服类固醇。对于所有具有高血栓形成风险的重症和非重症病例,建议进行血栓预防。抗生素治疗仅限于高度怀疑细菌二重感染的病例。出院后的轻中度和重症病例应至少进行两周的临床监测。